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白介素17在原发性膜性肾病患者血清和尿液中的表达
王群文,刘晓刚,解汝娟,高芃,刘亚楠,刘先双
0
(南京医科大学附属无锡人民医院急诊内科;哈尔滨医科大学附属第一医院肾内科)
摘要:
【摘要】目的 探讨IL17在原发性膜性肾病中的作用。方法 选取2016年6月~2018年2月哈尔滨医科大学附属第一医院43例原发性膜性肾病的患者,按照病理分期分为Ⅰ、Ⅱ、Ⅲ期3组,对所有患者的一般情况、实验室检查以及肾活检病理结果进行统计分析;另将43例患者按照有无肾小管及间质损伤分组,分析IL17与原发性膜性肾病患者肾小管及间质损伤的关系。结果 Ⅱ期和Ⅲ期血清IL17水平高于Ⅰ期(P<005),Ⅲ期尿液IL17水平高于Ⅱ期(P<005),Ⅲ期高于Ⅰ期和Ⅱ期(P<005);不同肾小管间质损伤程度的患者血清和尿液IL17表达水平比较差异均有统计学意义(P<005)。结论 IL17与原发性膜性肾病患者肾小管及间质损伤有关。
关键词:  白介素17  原发性膜性肾病  肾病综合征  肾小管间质损伤
DOI:
基金项目:
Expression of interleukin 17 in serum and urine of patients with primary membranous nephropathy
WANG Qunwen,LIU Xiaogang,XIE Rujuan,GAO Peng,LIU Yanan,LIU Xianshuang
(Department of Emergency Medicine, Wuxi People's Hospital Affiliated To Nanjing Medical University;Department of Nephrology, The First Affiliated Hospital, Harbin Medical University)
Abstract:
【Abstract】Objective The purpose of our study was to observe the expression of IL17 in serum and urine of patients with PMN and to explore the possible role of IL17 in PMN.Methods From June 2016 to February 2018, 43 patients with primary membranous nephropathy were selected from the First Affiliated Hospital of Harbin Medical University. According to the pathological stages, the patients were divided into three groups: stage Ⅰ, stage Ⅱ and stage Ⅲ. The general situation, laboratory examination and pathological results of renal biopsy were statistically analyzed. In addition, 43 patients were divided into groups according to whether there was renal tubule and interstitial damage, and the relationship between IL17 and renal tubule and interstitial damage in patients with primary membranous nephropathy was analyzed.Results The level of serum IL17 in stage Ⅱ and stage Ⅲ was higher than that in stage Ⅰ, with statistical difference (P<005). The level of urine IL17 in stage Ⅲ was higher than that in stage Ⅱ, with statistical difference (P<005). The level of serum and urine IL17 in stage Ⅲ was higher than that in stage Ⅰ and stage Ⅱ (P<005). The level of serum and urine IL 17 in patients with different degrees of tubulointerstitial injury was statistically different (P<005).Conclusion IL17 is associated with renal tubular and interstitial injury in patients with primary membranous nephropathy.
Key words:  Interleukin 17  Primary Membranous Nephropathy  Nephrotic Syndrome  Renal tubular and interstitial injury

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