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组织工程软骨的研究新进展
胡坤,陈竹,罗栩伟,冯刚
0
(西南医科大学;南充市中心医院精准医学中心;南充市中心医院·川北医学院第二临床医学院组织工程与干细胞研究所;;南充市中心医院精准医学中心;西南医科大学;南充市中心医院·川北医学院第二临床医学院组织工程与干细胞研究所;南充市中心医院精准医学中心)
摘要:
创伤、炎症、退行性变等各种原因导致的软骨损伤是临床上的常见病。由于软骨的自我修复能力极为有限,因此损伤软骨的修复一直是临床上亟待解决的问题。目前,传统治疗方法仍存在各种缺陷,组织工程技术则为损伤软骨的修复治疗带来了新的希望,被视为能从根本上解决损伤软骨的修复的方法之一。随着技术的发展,近年来组织工程软骨的研究取得了长足的进步,并相继有一些产品进入临床研究阶段。本文就组织工程技术在软骨修复领域中的研究新进展作一综述。
关键词:  组织工程软骨  种子细胞  支架  细胞因子  生物物理刺激
DOI:
基金项目:四川省教育厅科研项目(18ZB0206);南充市市校合作项目(NSMC20170203,NSMC20170310);南充市应用技术研究与开发资金项目(16YFZJ0024)
HU Kun,CHEN Zhu,LUO Xuwei,FENG Gang
(Southwest Medical University School;Institute of Tissue Engineering and Stem Cells, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital;Precision Medicine Center, Nanchong Central Hospital)
Abstract:
Cartilage injury caused by various causes such as trauma, inflammation, and degeneration is very common in clinic. Since the cartilage selfrepair ability is extremely limited, the cartilage repair is an urgent problem in clinic. Nowadays, there are still some problems about the traditional treatments. Tissueengineered cartilage is considered as a fundamental method for cartilage disease, and brings new hope for the repairmen of cartilage injury. With the development of technology, huge progress has been made about tissueengineered cartilage in recent years. Some products have been entered the clinical research stage. This review following primary introduces the new progress about tissueengineered cartilage.
Key words:  Tissue engineered cartilage  Seed cells  Scaffolds  Cytokines  Biophysical stimulation

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