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常规超声联合血清CA199和CA125检测在乳腺癌诊断中的应用
崔勇,唐一植,何自倩,李卫峰,青春
0
(三六三医院超声科;三六三医院病理科;三六三医院核医学科)
摘要:
目的 探讨常规超声联合血清CA199和CA125检测在乳腺癌诊断中的应用价值。方法 将182例乳腺肿块患者依据病理学检查结果分为乳腺癌组85例和乳腺良性肿瘤组97例,对患者进行常规超声检查并检测血清CA199和CA125水平。采用ROC工作曲线分析常规超声、CA199和CA125单独或联合检测诊断乳腺癌的效果。结果 与乳腺良性肿瘤比较,乳腺癌超声多表现为形状不规则、边界不清晰、有微小钙化灶、内部回声不均匀、纵横比≥1,差异具有统计学意义(P<0.05)。与乳腺良性肿瘤患者比较,乳腺癌患者的血清CA199和CA125水平明显升高,差异具有统计学意义(P<0.05)。常规超声、CA199和CA125诊断乳腺癌的ROC曲线下面积分别0.755、0.627和0.615,敏感度分别为72.2%、52.9%和37.6%,特异度分别为21.2%、60.8%和71.1%。三项指标联合检测诊断乳腺癌的ROC曲线下面积、敏感度、特异度分别为0.871、83.2%、65.3%,诊断效果明显优于单一指标检测。结论 常规超声联合血清C199和CA125检测在乳腺癌的诊断中具有一定的应用价值,三项联合应用有助于提升对乳腺癌的诊断效能。
关键词:  乳腺癌  诊断  常规超声  CA199  CA125
DOI:
基金项目:四川省科技厅重点研发项目(19ZDYF2063)
Application value of conventional ultrasound combined with serum CA199 and CA125 on diagnosis of breast cance
CUI Yong,TANG Yizhi,HE Ziqian,LI Weifeng,QING Chun
(Department of Ultrasound, 363 Hospital;Pathology Department, 363 Hospital;Nuclear Medicine Department, 363 Hospital)
Abstract:
Objective To explore the potential value of conventional ultrasound combined with CA199 and CA125 in diagnosis of breast cancer. Methods 182 patients with breast masses were divided into breast cancer group (85 cases) and benign breast cancer group (97 cases), according to the pathological results. The patients were examined by conventional ultrasound and the serum levels of CA199 and CA125 were detected. The ROC working curve was used to analyze the effects of conventional ultrasound, CA199 and CA125 alone or in combination to detect breast cancer. Results Compared with benign breast tumors, the ultrasound of breast cancer was more often characterized by irregular shape, unclear boundary, small calcification, uneven internal echo and aspect ratio ≥1, and the difference were statistically significant (P<0.05). Compared with patients with benign breast tumors, serum CA199 and CA125 levels were significantly higher in patients with breast cancer, and the difference were statistically significant (P<0.05). The areas under the ROC curve of conventional ultrasound, CA199 and CA125 for breast cancer diagnosis were 0.755, 0.627 and 0.615, with sensitivity of 72.2%, 52.9% and 376%, specificity of 21.2%, 60.8% and 71.1%, respectively. The area under the ROC curve, sensitivity, specificity of the combined detection of the three indicators were 0.871, 83.2%, 65.3%respectively, and the diagnostic effect was better than that of the single indicator detection. Conclusion Conventional ultrasound, CA199 and CA125 detection have certain application value in the diagnosis of breast cancer, and the combined detection of the three can help improve the diagnostic efficiency.
Key words:  Breast cancer  Diagnosis  Conventional ultrasound  CA199  CA125

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