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血清mir-34a和Sirt1水平与老年脑梗死患者颈动脉粥样硬化斑块稳定性的关系
唐宇姣,冯贤荣,杨东东,王宝佳,李启正
0
(内江市第一人民医院内五科;成都中医药大学附属医院神经内科;成都中医药大学基础医学院)
摘要:
目的 分析血清microRNA-34a(mir-34a)、沉默信息调节因子1(Sirt1)水平与老年脑梗死患者颈动脉粥样硬化斑块稳定性的关系。方法 选取2018年2月~2019年2月内江市第一人民医院收治的102例老年脑梗死患者作为脑梗死组,另选取同期入院体检的50例健康者作为对照组。均行颈动脉超声检查,分为斑块形成组及斑块未形成组(其中又分为不稳定斑块组和稳定斑块组),并检测各组血清mir-34a、Sirt1水平。结果 脑梗死组血清mir-34a水平显著高于对照组,血清Sirt1水平显著低于对照组(P<0.05);斑块形成组血清mir-34a水平显著高于斑块未形成组,血清Sirt1水平显著低于斑块未形成组(P<0.05);血清mir-34a水平预测斑块形成的AUC值为0.913,敏感度及特异度为82.90%、85.70%;血清Sirt1水平预测斑块形成的AUC值为0.874,敏感度及特异度为71.40%、91.50%;不稳定斑块组血清mir-34a水平显著高于稳定斑块组,血清Sirt1水平显著低于稳定斑块组(P<0.05);血清mir-34a水平预测斑块稳定性的AUC值为0.767,敏感度及特异度为51.00%、90.90%;血清Sirt1水平预测斑块稳定性的AUC值为0.756,敏感度及特异度为57.60%、87.80%。结论 血清mir-34a、Sirt1水平异常与脑梗死患者颈动脉粥样硬化斑块形成及其稳定性密切相关,可将其作为脑梗死的预警指标。
关键词:  microRNA-34a  沉默信息调节因子1  脑梗死  颈动脉粥样硬化斑块  稳定性
DOI:
基金项目:四川省科技厅重点研发项目(2017SZ0007)
Relationship between serum mir-34a and Sirt1 levels and stability of carotid atherosclerotic plaque in elderly patients with cerebral infarction
TANG Yujiao,FENG Xianrong,YANG Dongdong,WANG Baojia,LI Qizheng
(Department of Internal Medicine, The First People's Hospital of Neijiang;Department of Neurology, The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine;School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine)
Abstract:
Objective To analyze the relationship between levels of serum microRNA-34a (mi-34a) and silent information regulator 1 (Sirt1) and stability of carotid atherosclerotic plaque in elderly patients with cerebral infarction. Methods 102 elderly patients with cerebral infarction admitted to the hospital from February 2018 to February 2019 were enrolled as cerebral infarction group. 50 healthy subjects who were admitted to the hospital for physical examination at the same period were selected as control group. They were given carotid ultrasonography, and were divided into plaque formation group and nonplaque formation group (including unstable plaque group and stable plaque group). The levels of serum mir-34a and Sirt1 were measured among each group. Results The serum mir34a level in cerebral infarction group was significantly higher than that in control group, while the serum Sirt1 level was significantly lower than that in control group (P<0.05). The serum mir34a level in plaque formation group was significantly higher than that in nonplaque formation group while the serum Sirt1 level was significantly lower than that in nonplaque formation group (P<0.05). The AUC value, sensitivity and specificity of serum mir34a level in predicting plaque formation were 0.913, 82.90% and 85.70%. The AUC value, sensitivity and specificity of serum Sirt1 level in predicting plaque formation were 0.874, 71.40% and 91.50%. The serum mir-34a level in unstable plaque group was significantly higher than that in stable plaque group while the serum Sirt1 level was significantly lower than that in stable plaque group (P<0.05). The AUC value, sensitivity and specificity of serum mir-34a level in predicting plaque stability were 0.767, 51.00% and 90.90%. The AUC value, sensitivity and specificity of serum Sirt1 in predicting plaque stability were 0.756, 57.60% and 87.80%. Conclusion The abnormal levels of serum mir34a and Sirt1 are closely related to the formation and stability of carotid atherosclerotic plaque in patients with cerebral infarction, and they can be used as early warning indicators of cerebral infarction.
Key words:  microRNA-34a  Silent information regulator 1  Cerebral infarction  Carotid atherosclerotic plaque  Stability

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