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不同口服降糖药对2型糖尿病胰岛素泵强化治疗患者胰岛功能及预后的影响
许桂煌,张莹,郑思远,刘恩,罗恒聪
0
(广州医科大学;广州医科大学附属第三医院内分泌科)
摘要:
目的 探讨不同口服降糖药对2型糖尿病胰岛素泵强化治疗患者胰岛功能及预后的影响。方法 选择 2018年11月〜2019年7月来我院治疗2型糖尿病患者的103例作为研究对象,用随机数字表法将其分为观察组52例 和对照组51例,观察组釆用胰岛素泵强化联合达格列净治疗,对照组采用胰岛素泵强化联合二甲双脈治疗。比较两组 治疗前后血糖相关指标、临床相关指标、治疗后胰岛素用量、血糖完全达标人数、血糖达标时间、体重增加值。结果 治疗后2个月,观察组空腹血糖(FBG)、平均餐后2h血糖(2hBG)、高血糖百分比、糖化血红蛋白(HbAQ均明显低达对照 组,且低血糖百分比明显高于对照组(P<0. 05);观察组体重、血压、餐后2hC肽、总胆固醇(TC)、甘油三酯(TG)、高密度 脂蛋白胆固醇(HDL C)及胰岛(3细胞功能指数(HOMA阳均明显低于对照组,且空腹C肽及胰岛素抵抗指数(HOMA IR)均明显高于对照组(P<0. 05) ;观察组治疗后胰岛素用量、血糖达标时间、体重增加值均明显低于对照组,同时血糖 完全达标人数率高于对照组(95. 00 vs 68.42)%(P<0. 05)。结论 二甲双脈和达格列净两种降糖药治疗2型糖尿病 均有一定效果,但达格列净对降低血糖与临床相关指标效果更为显著,可在临床推广应用。
关键词:  2型糖尿病  达格列净  二甲双脈  降糖  胰岛素泵强化
DOI:
基金项目:广东省自然科学基金(218811)
Effects of different oral hypoglycemic agents on pancreatic islet function and prognosis of type 2 diabetic patients treated with insulin pump
XU Guihuang,ZHANG Ying,ZHENG Siyuan,LIU En,LUO Hengcong
(Guangzhou Medicdl University;Department of Endocrinology,The Third A ffiliated Hospital of Guangzhou Medical University)
Abstract:
Objective To explore the effect of different oral hypoglycemic drugs on islet function and prognosis in patients with type 2 diabetes mellitus treated by intensive insulin pump. Methods 103 patients with type 2 diabetes trea ted in our hospital from July 2016 to July 2019 were selected as research objects. They were divided into observation group (n=52) and control group (n=51) by random number table method. Blood glucose related indicators before and after treatment, clinical related indicators, post treatment insulin dosage, the number of patients with blood glucose reac hing the standard, the time of blood glucose reaching the standard, and the added value of body weight were compared between the two groups. Results 2 months after treatment, FBG, 2hBG,percentage of hyperglycemia, and HbAlc in the observation group were significantly lower than those in the control group. The percentage of hypoglycemia in the obser vation group was significantly higher than that in the control group (P<0. 05 ). Body weight, blood pressure, 2hC peptide, TC, TG,in the observation group were significantly lower than those in the control group. The fasting c peptide in the observation group were significantly higher than those in the control group (P<0. 05). After treatment, insulin, dosage ? blood glucose standard time and added value of body weight in the observation group were significantly lower than those in the control group. The rate of blood glucose standard in the observation group was higher than that in the control group (94.23 vs 80. 39)% (P<0. 05 ). Conclusion Metformin and daglidene both have certain effects in the treatment of type 2 diabetes, but daglidene has more significant effects on reducing blood glucose related indicators and clinical related indicators, which is worthy of clinical promotion and application
Key words:  Type 2 diabetes  Dapagliflozin  Metformin  Hypoglycemic  Insulin pump enhancement

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