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YAP和E-cadherin及Vimentin蛋白在宫颈鳞状细胞癌组织中的表达及其意义
唐波,梁静,甘中华,王洪飞,高杰,王茂霞,孙玲
0
(西南医科大学附属中医医院病理科;西南医科大学附属中医医院超声科)
摘要:
目的 探讨YAP蛋白和上友间质转化(EMT)相关蛋白E cadherin. Vimentin在宫颈鳞状细胞癌的表达及临床意义。方法 采用免疫组化法检测20例正常宫颈、50例鳞状上皮内病变及125例宫颈鳞状细胞癌组织中YAP 和EMT相关蛋白E cadherin、Vimentin的表达,并分析其与临床病理特征的关系。结果 在宫颈鳞状细胞癌组织中 YAP、E cadherin和Vimentin阳性表达率分别为71. 20%、55. 20%和48. 80% ,与鳞状上皮内病变和正常宫颈组织比较, 差异有统计学意义(P<0. 001) ; YAP蚤白的表达与组织学分级及淋巴结转移有关(P<0. 05); E cadherin及Vimentin 蛋白的表达与组织学分级、FIGO分期及淋巴结转移有关(P<0. 05),与其它临床病理参数无关(P>0. 05); YAP的表达 与E cadherin的表达呈负相关关系(t= 0. 395 ,P<0. 05),而与Vimentin的表达呈正相关关系(t=0. 338,P<0. 001)弋 结论 YAP蛋白的表达可能与宫颈鳞状细胞癌的发生发展有关,可能通过调控EMT促进宫颈鳞状细胞痛的浸润 转移。
关键词:  YAP  上皮冋质转化  宫颈鳞状细胞痛  E-cadherin蛋白  Vimentin蛋白
DOI:
基金项目:
Expression and significance of YAP E-cadherin and Vimentin in cervical squamous cell carcinoma
TANG Bo,LIANG Jing,GAN Zhonghua,WANG Hongfei,GAO Jie,WANG Maoxia,SUN Lingi
(Department of Pathology,Traditional Chinese Medicine Hospital Affiliated to Southujest Medical University;DepartTnent of Ultrasound , Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University)
Abstract:
Objective To evaluate the expression of YAP protein and epithelial mesenchymal transition (EMT) associated proteins E cadherin and Vimentin in cervical squamous cell carcinoma and its clinical significance. Methods Expression level of YAP protein and EMT associated proteins E cadherin and Vimentin proteins in cervical carcinoma were detected by imm uno his tochemical method in 20 normal cervix, 50 cases SIL and 125 cases cervical squamous cell carcinoma. The relation with clinical pathologic parameters was analyzed. Results The positive expression rate of YAP, E cadherin and Vimentin were 71. 20%, 55. 20% and 48. 80%, Compared with SIL and normal cervical tissue (P<0. 05). YAP expression was significant correlation with the degree of histological grade and lymph node metastasis (P<0. 05) , E cadherin and Vimentin expression were significant correlation with the degree of histological grade, FIGO stage and lymph node metastasis (P<0. 05) , but there was not obviously correlated with other clinical pathological parameters (P>0. 05). YAP expression was negative correlated with E cadherin (r=-0. 395 , P<0. 05) , YAP expression was pos itive correlated with Vimentin (r=0. 338, P<0. 05). Conclusion The expression of YAP protein may be related to the occurrence and development of cervical squamous cell carcinoma, and may promote the invasion and metastasis of cervical squamous cell carcinoma by regulating EMT.
Key words:  YAP  EMT  Cervical squamous cell carcinoma  E-cadherin  Vimentin

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