引用本文:[点击复制]
[点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 34次   下载 5 本文二维码信息
码上扫一扫!
血清PLA2R1和IgG联合检测对特发性膜性肾病的诊断价值
陈丽,汪洪,戴红英,任婷婷,易锐
0
(四川大学华西广安医院肾脏内科;岳池县人民医院检验科;成都市第十一人民医院肾脏内科;成都市郫都区中医医院肾内科)
摘要:
【摘要】 目的 探讨血清M型磷脂酶A2受体1(PLA2R1)、免疫球蛋白G(IgG)联合检测在特发性膜性肾病(IMN)中的诊断价值。 方法 抽取四川大学华西广安医院肾内科收治的96例肾病综合征患者行前瞻性研究,包括52例IMN患者、24例继发性膜性肾病(SMN)患者与20例不典型膜性肾病(AMN)患者,分别纳入IMN组、SMN组、AMN组,比较3组一般临床资料、实验室指标[白蛋白(ALB)、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血清肌酐(Scr)、肾小球滤过率(eGFR)、24h尿蛋白定量、血清PLA2R1、IgG],并分析血清PLA2R1、IgG对IMN的诊断敏感度与特异度。 结果 3组血清PLA2R1比较,IMN组>AMN组>SMN组,组间比较差异均有统计学意义(P<0.05);IMN组血清IgG水平明显高于SMN组(P<0.05);血清PLA2R1对IMN的诊断敏感度、特异度为77.36%、89.85%,ROC曲线下面积(AUC)为0.801;血清IgG分别为60.37%、71.25%,AUC为0.713;血清PLA2R1、IgG联合诊断敏感度、特异度为80.14%、93.78%,AUC为0.912。 结论 IMN患者血清PLA2R1、IgG水平异常升高,二者联合检测有助于IMN的临床诊断。
关键词:  特发性膜性肾病  M型磷脂酶A2受体1  免疫球蛋白G  联合检测
DOI:
基金项目:四川省科技厅资助项目
Diagnostic value of serum PLA2R1 and IgG combination detection for idiopathic membranous nephropathy
CHEN Li,WANG Hong,DAI Hongying,REN Tingting,YI Rui
(Department of Nephrology, West China Guang′an Hospital, Sichuan University;Department of Clinical Laboratory, Yuechi County People′s Hospital;Department of Nephrology, Chengdu 11th People′s Hospital;Department of Nephrology, Pidu Hospital of Traditional Chinese Medicine)
Abstract:
【Abstract】 Objective To observe the diagnostic value of combined detection with serum Mtype phospholipase A2 receptor 1 (PLA2R1) and immunoglobulin G (IgG) in idiopathic membranous nephropathy (IMN). Methods 96 patients with nephrotic syndrome admitted to the hospital were enrolled, including 52 IMN patients, 24 patients with secondary membranous nephropathy (SMN) and 20 patients with atypical membranous nephropathy (AMN). They were included in IMN group, SMN group and AMN group, respectively. The general clinical data and laboratory indexes [albumin (ALB), serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipid Protein cholesterol (LDL-C), serum creatinine (Scr), glomerular filtration rate (eGFR), 24h urine protein quantitation, serum PLA2R1, IgG] were compared among the 3 groups. The diagnostic sensitivity and specificity of serum PLA2R1 and IgG for IMN were analyzed. Results The serum PLA2R1 was the highest in IMN group, followed by AMN group and SMN group (P<0.05). The serum IgG level of IMN group was significantly higher than that of SMN group (P<0.05). ROC curve analysis showed that the diagnostic sensitivity, specificity and AUC of serum PLA2R1 for IMN were 77.36%, 89.85% and 0.801, respectively. The above indexes of serum IgG were 60.37%, 71.25% and 0.713, respectively. And above indexes of their combination diagnosis were 80.14%, 93.78% and 0.912, respectively. Conclusion Serum PLA2R1 and IgG combination detection can improve diagnostic sensitivity and specificity for IMN, which helps to identify IMN, AMN and SMN clinically.
Key words:  Idiopathic membranous nephropathy  M type phospholipase A2 receptor 1  Immunoglobulin G  Diagnosis

用微信扫一扫

用微信扫一扫