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金双歧联合有氧运动对老年腹泻型肠易激综合征患者的效果
王涛,胥渝,张勋,涂杰霞,杨乐
0
(绵阳四〇四医院药剂科)
摘要:
【摘要】 目的 探讨双歧杆菌乳杆菌三联活菌片(金双歧)联合有氧运动对老年腹泻型肠易激综合征(Diarrhea Irritable Bowel Syndrome,IBSD)患者的效果。方法 将2017年1月~2018年10月在本院接受诊治的老年IBS-D患者按照随机数字表法分为对照组和观察组,每组各86例。对照组患者接受金双歧治疗,2 g/次,3次/天,连续12周。观察组患者在对照组的基础上进行有氧运动,5次/周,连续12周。比较两组患者的症状评分、治疗效果、血清P物质(Substance P,SP)、神经肽Y(Neuropeptide Y,NPY)、肿瘤坏死因子α(Tumor Necrosis Factorα,TNF-α)和白细胞介素 6(Interleukin 6,IL-6)水平以及汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)和汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)评分。 结果 经过12周的治疗后,观察组患者的腹痛、腹胀、大便性状、排便频率、HAMD和HAMA评分明显低于对照组,差异均有统计学意义(P<0.05);观察组总有效率为91.86%,对照组总有效率为73.26%,两组的差异有统计学意义(P<0.001);观察组患者的血清NPY水平明显高于对照组,SP、TNF-α和IL-6水平明显低于对照组,差异均有统计学意义(P<0.05)。结论 金双歧联合有氧运动通过调控SP和NPY释放,减轻炎症状态而协同改善老年IBS-D患者的临床症状以及抑郁、焦虑情绪,治疗效果优于金双歧单一治疗。
关键词:  腹泻型肠易激综合征  老年  金双歧  有氧运动  联合治疗  SP  NPY
DOI:
基金项目:四川省医学会科研课题
Effect of Golden Bifid combined with aerobic exercise on elderly patients with diarrhea irritable bowel syndrome
WANG Tao,XU Yu,ZHANG Xun,TU Jiexia,YANG Le
(Pharmacy Department, Sichuan Mianyang 404 Hospital)
Abstract:
【Abstract】 Objective To investigate the effect of Bifidobacterium triple viable tablet (Golden Bifid) combined with aerobic exercise on elderly patients with diarrhea irritable bowel syndrome (IBS d). Methods According to the method of random number table, the elderly IBS D patients who were treated in our hospital from January 2017 to October 2018 were divided into control group and observation group with 86 cases in each group. The patients in the control group were treated with bifidus aureus 2 g / time, 3 times / day for 12 weeks. The patients in the observation group took aerobic exercise on the basis of the control group, 5 times / week, for 12 weeks. The symptom score, therapeutic effect, serum substance P (SP), neuropeptide Y (NPY), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), Hamilton Depression Scale (HAMD) and anxiety scale (HAMA) were compared between the two groups. Results After 12 weeks of treatment, the abdominal pain, abdominal distention, stool characteristics, defecation frequency, HAMD and HAMA scores of the observation group were significantly lower than those of the control group (P<0.05). The total effective rate of the observation group was 9186%, and that of the control group was 7326%. The difference between the two groups was statistically significant (center 2=21.320, P<0.001). The level of serum NPY in the observation group was significantly higher than that in the control group, and the levels of SP, TNF-α and IL-6 were significantly lower than that in the control group (P<0.05). Conclusion By regulating SP and NPY release and alleviating inflammatory state, Golden Bifid combined with aerobic exercise can improve the clinical symptoms, depression and anxiety of elderly IBS D patients. The therapeutic effect of Golden Bifid combined with aerobic exercise is better than that of Golden Bifid alone.
Key words:  Diarrhea predominant irritable bowel syndrome  Elderly  Golden Bifid  Aerobic exercise  Combination therapy  SP  NPY

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