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前列地尔联合阿德福韦酯治疗肝炎肝硬化的疗效及对TGF-β1与肝功能的影响
王国英,由军宁,曹中强,宋平辉,张彦
0
(延安大学咸阳医院普外科;陕西中医药大学附属医院外六科;核工业二一五医院普外三科)
摘要:
【摘要】 目的 探讨前列地尔联合阿德福韦酯治疗肝炎肝硬化的疗效及对转化生长因子β1(TGF-β1)、肝功能的影响。 方法 选取2017年3月~2019年3月于我院进行治疗的肝炎肝硬化患者298例,以随机数表法分为观察组(150例)和对照组(148例),对照组使用阿德福韦酯治疗,观察组在对照组的基础上加用前列地尔进行治疗。比较两组的临床疗效、血清TGF-β1、肿瘤坏死因子α(TNF-α)、透明质酸(HA)、III型前胶原(PCIII)、层粘连蛋白(LN)、总胆红素(TBil)、白蛋白(Alb)、丙草转氨酶(AST)水平变化及并发症发生情况。结果 观察组总有效率高于对照组(P<0.05);两组患者血清TGF-β1、TNF-α水平均较治疗前显著改善,且观察组患者TGF-β1、TNF-α水平均低于对照组(P<0.05);两组患者血清HA、PCIII、LN水平均较治疗前显著改善,且观察组患者HA、PCIII、LN水平均低于对照组(P<0.05);两组患者TBil、Alb 、AST水平均较治疗前显著改善,且观察组患者TBil、Alb 、AST水平较对照组改善更明显(P<0.05);两组患者并发症总发生率比较对照组高于观察组,差异有统计学意义(P<0.05)。 结论 在肝炎肝硬化患者中使用前列地尔联合阿德福韦酯效果显著,可有效改善患者血清TGF-β1及肝功能水平。
关键词:  肝炎  肝硬化  前列地尔  阿德福韦酯  转化生长因子 β1  肝功能
DOI:
基金项目:
Efficacy of alprostadil combined with adefovir dipivoxil in the treatment of hepatocirrhosis and its effect on TGF-β 1 and liver function
WANG Guoying,YOU Junning,CAO Zhongqiang,SONG Pinghui,ZHANG Yan
(Department of General Surgery, Xianyang Hospital, Yan'an University;The Sixth Departments of Surgery, The Affiliated Hospital of Shanxi University of Traditional Chinese Medicine;General Surgery, 215 Hospital of Nuclear Industry)
Abstract:
【Abstract】 Objective To investigate the effect of alprostadil combined with adefovir dipivoxil in the treatment of liver cirrhosis and the effect on transforming growth factorβ1 (TGF-β1) and liver function. Methods 298 patients with hepatitis and cirrhosis treated in our hospital from March 2017 to March 2019 were randomly divided into observation group (150 cases) and control group (148 cases). The control group was treated with adefovir dipivoxil, and the observation group was treated with alprostadil on the basis of the control group. The clinical effect, serum TGF-β1, TNF-α, yaluronic acid (HA), procollagen III (PCIII), laminin (LN), total bilirubin (TBIL), albumin (ALB), alanine aminotransferase (AST) and complications of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group (P<0.05). The serum levels of TGF-β1 and TNF-α in the two groups were significantly improved compared with those before treatment, and the levels of TGF-β1 and TNF-α in the observation group were lower than those in the control group (P<0.05). The levels of serum HA, PCIII and LN in the two groups were significantly improved compared with those before treatment, and the levels of HA, PCIII and LN in the observation group were lower than those in the control group (P<0.05). The levels of TBIL, ALB and AST in the two groups were significantly improved compared with those before treatment, and the levels of TBIL, ALB and AST in the observation group were significantly improved compared with those in the control group (P<0.05). The total incidence of complications in the two groups was significantly higher than that in the control group (P<0.05). Conclusion The combination of alprostadil and adefovir dipivoxil in patients with hepatitis and cirrhosis is effective in improving the level of serum TGF-β 1 and liver function.
Key words:  Hepatitis  Cirrhosis of the liver  Alprostadi  Adefovir dipivoxil  Convert growth factor beta 1  Liver function

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