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卡前列素氨丁三醇联合米索前列醇治疗凶险性前置胎盘剖宫产术后出血
黄水玉,涂荧花,胡韵婷,曾笑梅,王骞
0
(福建医科大学附属宁德市医院妇产科)
摘要:
【摘要】 目的 探讨卡前列素氨丁三醇联合米索前列醇治疗凶险性前置胎盘剖宫产术后出血的临床疗效。 方法 选择2017年1月~2019年10月我院收治的凶险性前置胎盘患者50例,随机分为观察组(n=26)和对照组(n=24)。对照组使用米索前列醇治疗,观察组在对照组的基础上加用卡前列素氨丁三醇进行治疗。比较两组患者的临床疗效、术中、术后出血量及止血时间、输血情况、住院时间、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、不良反应的发生情况。 结果 观察组总有效率高于对照组,差异有统计学意义(P<0.05);观察组术中、术后2小时及术后24小时出血量均显著低于对照组(P<0.05);观察组止血时间、输血及住院时间均显著低于对照组(P<0.05);治疗后,两组凝血功能均显著改善,且观察组PT、APTT、TT水平高于对照组(P<0.05);观察组不良反应总发生率明显少于对照组,差异有统计学意义(P<0.05)。 结论 卡前列素氨丁三醇联合米索前列醇在预防凶险性前置胎盘剖宫产术后出血中效果显著,安全性较高,可供临床医师借鉴。
关键词:  凶险性前置胎盘  卡前列素氨丁三醇  米索前列醇  剖宫产  术后出血
DOI:
基金项目:福建省卫生健康青年科研计划项目
Combination of carboprost and misoprostol in the treatment of dangerous bleeding after cesarean section of placenta previa
HUANG Shuiyu,TU Yinghua,HU Yunting,ZENG Xiaomei,WANG Qian
(Department of Obstetrics and Gynecology, Ningde Hospital Affiliated to Fujian Medical University)
Abstract:
【Abstract】 Objective To investigate the clinical effect of carboprost and misoprostol in the treatment of bleeding after cesarean section of placenta previa. Methods From January 2017 to October 2019, 50 patients with dangerous placenta previa were randomly divided into observation group (n = 26) and control group (n = 24). The control group was treated with misoprostol, and the observation group was treated with carboprost and aminobutriol on the basis of the control group. The clinical effect, intraoperative and postoperative bleeding volume, hemostasis time, blood transfusion, hospitalization time, prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). The amount of bleeding in the observation group was significantly lower than that in the control group (P<0.05). The hemostasis time, blood transfusion and hospital stay time in the observation group were significantly lower than those in the control group (P The levels of APTT and TT in the observation group were higher than those in the control group (P<0.05), and the total incidence of adverse reactions in the observation group was significantly lower than that in the control group (P<0.05). Conclusion The combination of carboprost and misoprostol is effective and safe in the prevention of bleeding after cesarean section of placenta previa.
Key words:  Placenta previa  Ann column g  Misoprostol  Cesarean section  Postoperative bleeding

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