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纳米银敷料联合中药补阳还五汤治疗糖尿病足溃疡
彭杨,秦花,覃岭
0
(成都医学院第一附属医院烧伤科)
摘要:
【摘要】 目的 观察纳米银敷料联合中药补阳还五汤对糖尿病足溃疡的临床疗效。 方法 选取我院2016年3月~2018年3月收治的128例糖尿病足溃疡患者,将其随机分为对照组、治疗组1、治疗组2和联合治疗组,每组32例。对照组给予常规外科换药处理及糖尿病足内科治疗,治疗组1采用隔日更换1次纳米银敷料覆盖,治疗组2给予口服中药补阳还五汤,联合治疗组采用隔日更换1次纳米银敷料覆盖和口服中药补阳还五汤治疗。治疗前及治疗后第12、24、48 d取伤口分泌物行细菌培养,每次更换敷料时测量伤口面积,检测红细胞沉降率、CRP、胱抑素C。 结果 联合治疗组12、24、48 d糖尿病足溃疡病原菌阳性率低于同期对照组 (P<0.05),联合治疗组12、24、48 d后伤口面积明显小于同期对照组(P<0.05),伤口愈合率高于对照组(P<0.05),红细胞沉降率、CRP和胱抑素C低于同期对照组(P<0.05)。治疗组1和治疗组2疗效与同期对照组比较差异无统计学意义(P>0.05)。 结论 纳米银敷料联合中药补阳还五汤治疗糖尿病足溃疡能有效抑制溃疡局部细菌生长,促进伤口愈合,提高糖尿病足溃疡愈合的临床疗效。
关键词:  糖尿病足  溃疡  补阳还五汤  纳米银敷料  胱抑素C
DOI:
基金项目:
The clinical effect of nano silver dressing combined with Buyang Huanwu decoction on diabetic foot ulcer
PENG Yang,QIN Hua,QIN Ling
(Department of Burn, The First Affiliated Hospital of Chengdu Medical College)
Abstract:
【Abstract】 Objective To observe the clinical effect of nano silver dressing combined with Buyang Huanwu decoction on diabetic foot ulcer. Methods From March 2016 to March 2018, 128 patients with diabetic foot ulcer were randomly divided into control group, treatment group 1, treatment group 2 and combined treatment group. The control group was treated with routine surgical dressing change and diabetic foot medicine. Treatment group 1 was covered with nano silver dressing every other day. Treatment group 2 was treated with Buyang Huanwu decoction. In the combined treatment group, the nano silver dressing was replaced every other day and the traditional Chinese medicine Buyang Huanwu decoction was taken orally. Before treatment and on the 12th, 24th and 48th day after treatment, the secretion of the wound was taken for bacterial culture, the wound area was measured each time the dressing was changed, the erythrocyte sedimentation rate, CRP and cystatin C were detected. Results The positive rate of pathogenic bacteria of diabetic foot ulcer in the combined treatment group was lower than that in the control group (P<0.05). The wound area of the combined treatment group was significantly smaller than that of the control group (P<0.05). The wound healing rate was higher than that of the control group (P<0.05). The erythrocyte sedimentation rate, CRP and cystatin C were lower than those of the control group (P<0.05). There was no significant difference between treatment group 1 and treatment group 2 and control group at the same time (P>0.05). Conclusion Nano silver dressing combined with Buyang Huanwu decoction can effectively inhibit the growth of bacteria in diabetic foot ulcer, promote wound healing and improve the clinical effect of diabetic foot ulcer healing.
Key words:  Diabetic foot  Ulcer  Buyang Huanwu Decoction    Nano silver dressing  Cystatin C

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