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血清Mb、cTnT和hs CRP检测在充血性心力衰竭中的临床意义
刘利君,何元军,张邱兵,何平,伏俊,赵诤
0
(广元市中心医院心血管一科;广元市中心医院检验科)
摘要:
目的 探讨血清肌红蛋白(Mb)、心肌肌钙蛋白T(cTnT)和超敏C反应蛋白(hs-CRP)检测在充血性心力衰竭中的临床意义。方法 选取我院2018年1月~2018年10月收治的120例充血性心力衰竭患者为为观察组,另将同期于我院体检的120例健康人为对照组。两组均进行血清Mb、cTnT和hs-CRP检测,评估血清Mb、cTnT和hs-CRP对充血性心力衰竭的诊断效能,并比较不同NYHA分级充血性心力衰竭患者血清Mb、cTnT及hs-CRP水平。 结果 观察组血清Mb、cTnT和hs-CRP水平均显著高于对照组(P<0.05);血清Mb、cTnT和hs-CRP诊断充血性心力衰竭的灵敏度分别为91.67%、70.83%、82.50%,特异度分别为78.33%、83.33%、63.33%。血清Mb、cTnT和hs-CRP联合检测对充血性心力衰竭的诊断灵敏度、特异度、准确度、阳性预测值和阴性预测值均高于单一检测。NYHA Ⅳ级患者血清Mb、cTnT和hs-CRP水平均显著高于NYHAⅡ级和Ⅲ级(P<0.05),NYHA Ⅲ级患者血清Mb、cTnT和hs-CRP水平均显著高于NYHAⅡ级(P<0.05)。 结论 血清Mb、cTnT及hs-CRP联合检测可提高充血性心力衰竭诊断效能,且血清Mb、cTnT和hs-CRP水平可有效评估患者NYHA分级,可作为充血性心力衰竭严重程度的评估指标。
关键词:  肌红蛋白  心肌肌钙蛋白Ⅰ  超敏C反应蛋白  充血性心力衰竭
DOI:
基金项目:四川省卫生和计划生育委员会科研课题(16003429)
Clinical significance of serum myoglobin, cardiac troponin T and high-sensitivity C-reactive protein levels in patients with congestive heart failure
LIU Lijun,HE Yuanjun,ZHANG Qiu Bing,HE Ping,FU Jun,ZHAO Zheng
(Cardiovascular Department, Guangyuan Central Hospital;Laboratory Department, Guangyuan Central Hospital)
Abstract:
Objective To investigate the clinical significance of serum myoglobin (Mb), cardiac troponin T(cTnT) and high-sensitivity C-reactive protein (hs-CRP) levels in patients with congestive heart failure. Methods 120 patients with congestive heart failure in the hospital were selected as the observation group, and 120 healthy people were used as the control group at the same time. Serum Mb, cTnT and hsCRP were detected. The diagnostic efficiencies of Mb, cTnT and hs-CRP for patients with congestive heart failure were evaluated. Serum Mb, cTnT and hsCRP levels in patients with different NYHA grades of congestive heart failure were compared. Results The levels of serum Mb, cTnT and hs-CRP in the observation group were significantly higher than those in the control group (P<0.05). The sensitivities of serum Mb, cTnT and hs-CRP for diagnosis of congestive heart failure were 91.67%, 70.83% and 82.50%, respectively.The specificities were 78.33%, 83.33% and 63.33%, respectively. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of combined diagnosis of serum Mb, cTnT and hs-CRP for congestive heart failure were higher than those of single detection. Serum Mb, cTnT and hs-CRP levels were significantly higher in NYHA grade IV patients than in NYHA grade Ⅱ and grade Ⅲ patients (P<0.05). Serum Mb, cTnT and hs-CRP levels in NYHA grade Ⅲ patients were significantly higher than those in NYHA grade Ⅱ patients (P<0.05). Conclusion Combined detection of serum Mb, cTnT and hs-CRP can improve the diagnostic efficiency of congestive heart failure. Besides, serum Mb, cTnT and hs-CRP levels can be used to effectively assess the NYHA grade, can be used as an index to evaluate the severity of congestive heart failure.
Key words:  Myoglobin  Cardiac troponin I  High sensitivity C reactive protein  Congestive heart failure

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