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肾痿复方治疗慢性肾脏疾病的临床疗效
李雪英,陈明,文集,樊均明
0
(成都中医药大学附属医院肾病一科;四川大学华西医院风湿免疫科;成都中医药大学附属医院肾病一科,四川大学国家重点实验室,成都医学院)
摘要:
目的 探讨肾痿复方治疗慢性肾脏疾病(CKD)的临床疗效。 方法 选取2016年12月~2018年12月成都中医药大学附属医院收治的CKD3-5期未透析门诊患者162例,按治疗方式分为对照组(n=82)和治疗组(n=80)。对照组给予常规西医治疗,治疗组在常规西医治疗的基础上加用中药肾痿复方治疗,两组均治疗24周。比较治疗后两组患者临床症状、尿素氮、肌酐、肾小球滤过率、尿蛋白、尿红细胞等指标。 结果 治疗组临床总有效率高于对照组,差异有统计学意义(P<0.05);治疗组降低尿素氮、血肌酐,升高肾小球滤过率的作用优于对照组,差异亦有统计学意义(P<0.05);两组在改善尿蛋白、尿红细胞方面比较,差异无统计学意义(P>0.05)。结论 肾痿复方配合常规西医治疗慢性肾脏疾病疗效显著,中西医结合治疗慢性肾脏疾病优于常规西医治疗。
关键词:  慢性肾脏疾病  肾痿复方  临床疗效
DOI:
基金项目:四川省青年科技基金(2011JTD0014);四川省中医院·成都中医药大学附属医院科技发展基金(2006-D-YY-24)
Efficacy of Shenwei compound on patients with chronic kidney disease
LI Xueying,CHEN Ming,WEN Ji,FAN Junming
(Hospital of Chengdu University of Traditional Chinese Medicine;Department of Rheumatology and Immunology, West China Hospital of Sichuan University,State Key Laboratory of Sichuan University, Chengdu Medical College)
Abstract:
Objective To investigate the efficacy of Shenwei compound, a traditional Chinese medicine, on patients with advanced chronic kidney disease (CKD). Methods 162 patients with CKD (stages III to V) without dialysis were recruited and randomly divided into control group (82 patients) and (treatment group 80 patients). All patients were followed up every month for 24 weeks. The control group was treated with routine western medicine for 24 weeks, while the treatment group was treated with traditional Chinese medicine Shenwei Compound for 24 weeks on the basis of routine western medicine. The clinical symptoms, urea nitrogen, creatinine, glomerular filtration rate, urinary protein and urinary erythrocyte of the two groups were observed before and after treatment. Results There was no significant difference in baseline data between treatment group and control group before treatment (P>0.05). The total clinical effective rate of treatment group was higher than that of control group(P<0.05). The serum creatinine, urea nitrogen and glomerular filtration rate of treatment group were better than that of control group (P<0.05). After 24 weeks of observation, there was no significant difference in the improvement of urinary protein and urinary erythrocyte between the two groups (P>0.05).Conclusion Shenwei Compound combined with western medicine has a remarkable curative effect on CKD. The combination of traditional Chinese and Western medicine is more useful than that of conventional western medicine in the treatment of CKD.
Key words:  Chronic kidney disease  Traditional Chinese medicine  Therapy outcome

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