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不规则抗体检测在临床用血及输血患者安全中的影响
毛凯,翟小燕,李晓雁,郭辉,张阳,王美妮
0
(宝鸡市中心医院输血科;宝鸡市中医医院骨关节二科)
摘要:
【摘要】 目的 探讨不规则抗体检测在临床用血及输血患者安全中的影响。方法 选取2016年1月~2017年8月期间输全血治疗的93例住院患者作为对照组(输血前未接受不规则抗体检测),另将2017年9月~2018年5月期间输全血治疗的93例住院患者作为观察组(输血前均接受不规则抗体检测,实验方法为微柱凝胶检验法)。统计分析两组患者输血反应发生情况,并将观察组不规则抗体检测情况、抗体筛查阳性分型结果进行分析。结果 观察组输血反应发生率明显低于对照组,差异有统计学意义(P<0.05)。观察组患者不规则抗体检测率结果中,男性与女性患者之间比较,差异无统计学意义(P>0.05);有妊娠史与无妊娠史患者之间比较,差异无统计学意义(P>0.05);而有输血史与无输血史患者之间比较,差异有统计学意义(P<0.05)。观察组患者不规则抗体筛查阳性分型以抗M和抗E为主,分别占3333%、2223%,抗D、抗s、抗K、抗c相对占比较低。结论〓输全血前对患者进行不规则抗体检测,并有针对性的采取预防措施,可有效提高临床用血安全,降低输血反应发生率。
关键词:  输血安全  不规则抗体  检测  临床用血  不良反应
DOI:
基金项目:
Effect of irregular antibody detection on the safety of clinical blood and transfusion patients
MAO Kai,ZHAI Xiaoyan,LI Xiaoyan,GUO Hui,ZHANG Yang,WANG Meini
(Blood Transfusion Division, Baoji City Central Hospital;Osteoarticular Second Department, Baoji Hospital of Traditional Chinese Medicine)
Abstract:
【Abstract】 Objective To explore the influence of irregular antibody detection on the safety of patients with clinical blood use and blood transfusion. Methods 186 patients were divided into observation group and control group according to the different time period of blood transfusion treatment, 93 cases each. The patients in the observation group were tested for irregular antibodies before blood transfusion(experimental method was microcolumn gel test), and preventive measures were taken. The control group did not carry out irregular antibody detection before blood transfusion treatment, and analyzed the occurrence of blood transfusion reaction in two groups of patients, and analyzed the irregular antibody detection and positive typing results of antibody screening in the observation group. Results The incidence of blood transfusion reaction in the observation group was 108 %, which was significantly lower than 1076 % in the control group(P>0.05). There was no significant difference between male and female in the results of irregular antibody detection(P >0.05). There was no statistically significant difference between patients with pregnancy history and those without pregnancy history(P > 0.05); The difference between patients with history of transfusion and patients with no history of transfusion was statistically significant(P<0.05). The positive types of irregular antibody screening in the observation group were mainly antiM and antiE, accounting for 3333 % and 22.23 %, respectively, and antiD, antis, antiK, and antic were relatively low. Conclusion Irregular antibody detection before whole blood transfusion and targeted preventive measures can effectively improve the safety of clinical blood use and reduce the incidence of transfusion reaction.
Key words:  Safety of blood transfusions  Irregular antibodies  Testing  Clinical blood use  Side effects

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