引用本文:[点击复制]
[点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 29次   下载 14 本文二维码信息
码上扫一扫!
风湿性心脏病患者外周血脂肪因子Chemerin与ILβ、IL-6及TNF-α表达的相关性
许锋成,曾洪燕,杜曦,秦亚录,刘天虎
0
(郫都区人民医院心内科)
摘要:
【摘要】 目的 探讨风湿性心脏病(Rheumatic Heart Disease,RHD)患者外周血脂肪因子Chemerin的表达与白介素1β(Interleukin1β,IL1β)、白介素6(Interleukin6,IL6)及肿瘤坏死因子α(Tumor necrosis factor,TNF)表达的相关性。方法 选择2017年1月~2018年6月我院心血管内科收治的38例风湿性心脏病患者设为RHD组,选择同期37例正常健康体检者设为对照组,检测两组外周血清脂肪因子Chemerin和IL1β、IL6、TNFα水平,了解其与风湿性心脏病发病的相关性。结果 RHD组外周血脂肪因子Chemerin表达水平及IL1β、IL6、TNFα水平均明显高于对照组,差异均有统计学意义(P<0.05);RHD组外周血脂肪因子Chemerin表达水平与外周血IL1β、IL6、TNFα呈正相关关系(P<0.01)。结论 风湿性心脏病患者外周血IL1β、IL6和TNFα升高及脂肪因子Chemerin表达增高与其发病相关,外周血脂肪因子Chemerin可能通过调节IL1β、IL6和TNFα的表达参与风湿性心脏病的发病。
关键词:  风湿性心脏病  脂肪因子Chemerin  白介素 1β  白介素 6  肿瘤坏死因子 α
DOI:
基金项目:四川省卫生厅科研课题
Changes in the expression of adipokine chemerin andIL 1β, IL-6 and TNF-α in peripheral blood of patients with rheumatic heart disease
XU Fengcheng,ZENG Hongyan,DU Xi,QIN Yalu,LIU Tianhu
(Department of Cardiology, Pidu People's Hospital)
Abstract:
【Abstract】 Objective To explore the correlation between the expression of adipokine chemerin and interleukin1β(IL1β), interleukin6 (IL6) and tumor necrosis factoralpha ( TNFα) in peripheral blood of patients with rheumatic heart disease (RHD).Methods 38 patients with RHD (experimental group) and 37 normal healthy subjects (control group) were enrolled in this study. The serum levels of adipokine chemerin, IL1β, IL6 and TNFα were measured by enzyme linked immunosorbent assay (ELISA).Results The expression of adipokine chemerin in peripheral blood of patients with rheumatic heart disease(RHD) was significantly higher than that in healthy subjects (P<0.05). Compared with the control group, expression of IL1β, IL6 and TNFα was apparently increased in patients with RHD (P<0.05). The expression of adipokine Chemerin in peripheral blood of patients with RHD was positively correlated with the expression of IL1β, IL6 and TNFα in patients of RHD (P<0.01).Conclusion Elevated levels of IL1 beta, IL6 and TNFαand increased expression of adipokine chemerin in peripheral blood of patients with RHD are associated with the pathogenesis of RHD. Adipokine chemerin may be involved in the pathogenesis of RHD by regulating the expression of IL1 beta, IL6 and TNF-α.
Key words:  Rheumatic heart disease  Chemerin  Interleukin 1β  Interleukin 6  Ttumor necrosis factor α

用微信扫一扫

用微信扫一扫