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小剂量阿司匹林治疗早发型子痫前期的疗效及对母婴结局的影响
赵金珩,王茜,桑雪梅,贾燚鑫,张桂欣,孙丽君
0
(唐山市妇幼保健院妇产科)
摘要:
【摘要】 目的 探讨小剂量阿司匹林治疗早发型子痫前期的疗效及对母婴结局的影响。方法 选取2016年1月~2018年1月期间我院收治的94例早发型子痫前期患者,分为对照组(常规治疗组)和观察组(阿司匹林抗凝组),每组各47例。对照组予以常规治疗,观察组在常规治疗基础上予以小剂量阿司匹林治疗。观察并记录两组患者疗程结束后的临床总有效率、凝血功能指标[血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fib)]、不良妊娠结局(肝肾功能异常、子痫、早产、剖宫产、产后出血)的发生率、围生儿结局[新生儿体质量、1min新生儿评分(Apgar)]以及治疗期间血小板计数异常、胃肠道症状等不良反应发生情况。结果 疗程结束后,观察组治疗总有效率明显高于对照组(P<0.05);观察组患者PT、APTT、TT均较对照组更长(P<0.05),血清Fbg水平则明显更低(P<0.05);两组剖宫产率、产后出血率差异无统计学意义(P>0.05);观察组肝肾功能损害、子痫、早产发生率均低于对照组(P<0.05);观察组新生儿体质量、1min Apgar评分均高于对照组(P<0.05);两组治疗期间均未出现血小板计数异常或明显的胃肠道症状(P>0.05)。结论 小剂量阿司匹林用于治疗早发型子痫前期是安全有效的,可保护患者肝肾功能,减少并发症,改善母婴结局。
关键词:  小剂量阿司匹林  早发型子痫前期  临床疗效  凝血功能  母婴结局
DOI:
基金项目:2017年度河北省医学科学研究重点课题
Efficacy of low dose aspirin on early onset preeclampsia and its effects on maternal infant outcomes
ZHAO Jinyan,WANG Qian,SANG Xuemei,JIA Yanxing,ZHANG Guixin,SUN Lijun
(Department of Gynaecology and obstetrics,Tangshan women and children Health Hospital)
Abstract:
【Abstract】 Objective To observe the efficacy of lowdose aspirin on earlyonset preeclampsia and its effects on maternalinfant outcomes. Methods 94 patients with earlyonset preeclampsia admitted to our hospital from January 2016 to January 2018 were selected and randomly divided into control group (conventional treatment group) and observation group (aspirin anticoagulation group) according to the order of admission, with 47 cases in each group. The two groups were given routine treatment, and observation group was given lowdose aspirin on this basis. The total clinical effective rate at the end of treatment, coagulation function indicators[plasma prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (Fib)], incidence rates of adverse pregnancy outcomes (abnormal renal and liver function, eclampsia, premature delivery, cesarean section, postpartum hemorrhage), perinatal outcomes[neonatal body weight, 1 min neonatal score (Apgar)]and platelets count abnormalities and occurrence of gastrointestinal symptoms during treatment were observed and recorded. Results At the end of treatment, the total effective rate of treatment in observation group was significantly higher than that in control group (P<0.05). The PT, APTT and TT in observation group were significantly longer than those in control group (P<0.05), and the serum Fbg level was significantly lower (P<0.05). There was no significant difference in the cesarean section rate and postpartum hemorrhage rate between the two groups (P>0.05). The incidence rates of liver function damage, renal function damage, eclampsia and preterm birth in observation group were lower than those in control group (all P<0.05). The neonatal body weight and 1min Apgar scores in observation group were higher than those in control group (P<0.05). There were no abnormal platelets count or obvious gastrointestinal symptoms during treatment. Conclusions Lowdose aspirin is safe and effective for the treatment of earlyonset preeclampsia, and it can protect liver and kidney function, reduce complications and improve maternalinfant outcomes.
Key words:  Low dose aspirin  Early onset preeclampsia  Clinical efficacy  Coagulation function  Maternal infant outcomes

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