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α2-肾上腺受体单核苷酸多态性与乳腺癌患者CRF的相关性研究
王梅芳,姚晚侠,李小妹,王娟,杨慧云
0
(西安交通大学城市学院护理系;西安交通大学第一附属医院肿瘤放射科;西安交通大学医学部;陕西省肿瘤医院乳腺科;西安交通大学第二附属医院护理部)
摘要:
【摘要】 目的 探讨乳腺癌癌性疲乏(CRF)与肾上腺素水平、α2肾上腺受体(α2AR)单核苷酸多态性(SNP)的相关性。方法 抽样法抽取2016年02月~2018年3月在陕西省肿瘤医院及西安交通大学第一、第二附属医院确诊并符合抽样标准的乳腺癌患者240例,分为手术组、化疗组和放疗组,每组各80例,测评其疲乏状况(轻、中、重度疲乏),并取外周静脉血,采用酶联免疫法测定其肾上腺素浓度,分析不同治疗期肾上腺素水平与癌性疲乏的关系。并将化疗组重度疲乏的59例患者设为病例组,选取同期59例健康人设为对照组,采用PCRRELP方法检测两组受试者的基因型,应用SPSS200统计软件分析α2A肾上腺受体单核苷酸多态性位点与癌性疲乏程度的关联性。结果 不同治疗期内,乳腺癌患者的疲乏程度均与血液中的肾上腺素水平呈正相关(P<0.05 )。同等疲乏程度的患者在不同治疗时期内,血液中的肾上腺素水平并不一致:重度疲乏者中,手术组肾上腺素水平显著高于放疗组 (t=237,P<0.05),化疗组显著高于放疗组 (t=315,P<0.01);中度疲乏者中,手术组肾上腺素水平显著高于化疗组(t=231,P<0.01)和放疗组 (t=604,P<0.05);轻度疲乏者中,手术组、化疗组和放疗组的肾上腺素水平差异无统计学意义(P<0.05)。病例组和对照组α2AAR1296位点的基因频数分布均符合HardyWeinberg平衡定律(P>0.05),两组α2AAR的基因型频数分布比较差异无统计学意义(2=1161,P>0.05)。结论 乳腺癌癌性疲乏程度与肾上腺素水平呈正相关,但可能与α2AAR1296位点基因多态性无关。
关键词:  乳腺癌  癌因性疲乏  单核甘酸多肽性  肾上腺素
DOI:
基金项目:陕西省教育厅2017年专项科学研究计划
Analysis on association between polymorphisms of α2A-AR and cancer related fatigue among breast cancer patients
WANG Meifang,YAO Wanxia,LI Xiaomei,WANG Juan,YANG Huiyun
(Department of Nursing, Xi'an Jiaotong University City College;Department of Cancer Radiology, The First Affiliated Hospital of Xi'an Jiaotong University;Medical Department, Xi'an Jiaotong University;Department of Mammary Gland, Shanxi Provincial Cancer Hospital;Department of Nursing, The Second Affiliated Hospital of Xi'an Jiaotong University)
Abstract:
【Abstract】 Objective To investigate the association between the level of adrenaline, the single nucleotide polymorphisms (SNPS) of alpha 2adrenal receptor, and cancerrelated fatigue (CRF) on breast cancer patients in the different treatment periods. Methods 240 patients diagnosed as breast cancer hospitalized from February 2016 to March 2018 in a tumor hospital and two affiliated hospitals of a medical college were divided into operation group, chemotherapy group and radiotherapy group, 80 cases in each group. The CRF of the patients was evaluated and peripheral venous blood was extracted in three different stages. The concentration of adrenaline was measured with ELISA. The genotype was detected by PCR RELP. The association between alpha 2A adrenoceptor single nucleotide polymorphism and cancer fatigue was analyzed with SPSS20_0 statistical software.Results In the different treatment periods, fatigue levels were positively correlated with the level of adrenaline in the blood (P<0.05). The level of adrenaline in the blood was not the same among patients suffering from the same level of fatigue in different periods of treatment. The adrenaline level of patients with severe fatigue was significantly higher in operation than that in period of radiotherapy (t=237, P<0.05). The adrenaline level of patients with moderate fatigue was significantly higher in operation than that in period of chemotherapy (t=231, P<0.01) and radiotherapy (t=604, P<0.05). The adrenaline level of patients with mild fatigue showed no statistical significance in three different treatment periods (P>0.05). The distribution of genotypic frequencies of SNPS sites didn't deviate from HardyWeinberg equilibrium in both case group and control group (P>0.05). The distribution of genotypic at α2AAR1296 site showed no statistical significance between case group and control group (2=1161, P>0.05). Conclusion CRF is positively correlated with the level of adrenaline in the blood. The polymorphism of α2AAR1296 site may be not associated with CRF.
Key words:  Breast cancer  Cancer related fatigue  Single nucleotide polymorphism  Adrenaline

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