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脑胶质瘤患者围术期脑氧代谢及MMP相关指标的变化研究
张家伟,王琨,唐文艳,宋波
0
(延安大学咸阳医院神经外科)
摘要:
【摘要】 目的 探讨脑胶质瘤患者围术期脑氧代谢及基质金属蛋白酶(matrix metalloprotinase,MMP)相关指标的变化情况。方法 选取2012年1月~2016年2月于本院进行手术治疗的38例脑胶质瘤患者为观察组,选取同期38例健康人员为对照组,将观察组术前1d、术后1、3、7、10、20d和对照组的脑氧代谢及MMP相关指标进行比较。结果 观察组术前1d及术后1、3、7、10d脑氧代谢指标均差于对照组(P<0.05),术前1d、术后1、3、7、10、20d血清MMP相关指标均高于对照组(P<0.05),而两组术后20d的脑氧代谢指标则无明显差异(P>0.05)。结论 脑胶质瘤患者围术期脑氧代谢及MMP相关指标的变化较大,尤其是术前及术后早期应加强对上述指标的监测及调节。
关键词:  脑胶质瘤  围术期  脑氧代谢  MMP相关指标
DOI:
基金项目:咸阳市科技计划项目
Study on the change of cerebral oxygen metabolism and MMP related indexes of patients with brain gliomas during the perioperative period
ZHANG Jiawei,WANG Kunjie,TANG Wenyan,SONG Bo
(Department of Neurosurgery, Xianyang Hospital, Yan 'an University)
Abstract:
【Abstract】 Objective To study and observe the change situation of cerebral oxygen metabolism and MMP related indexes of patients with brain gliomas during the perioperative period. Methods 38 patients with brain gliomas treated with operation in our hospital from January 2014 to February 2016 were selected as the observation group. 38 healthy personnel at the same stage were selected as the control group. The cerebral oxygen metabolism and MMP related indexes of observation group at first day before the operation and at first,third,seventh,tenth and twentieth day after the operation were compared.Results The cerebral oxygen metabolism indexes of observation group at first day before the operation and at first,third,seventh and tenth day after the operation were all worse than those of control group. The serum MMP related indexes at first day before the operation and at first,third,seventh,tenth and twentieth day after the operation were all higher than those of control group ( P<0.05). The cerebral oxygen metabolism indexes of two groups at twentieth day after the operation all had no obvious differences ( P>0.05). Conclusion The change of cerebral oxygen metabolism and MMP related indexes of patients with brain gliomas during the perioperative period are great,and the those indexes early before and after the operation should be paid more monitoring and regulation.
Key words:  Brain gliomas  Perioperative period  Cerebral oxygen metabolism  MMP related indexes

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