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宫颈癌组织中BIM和PUMA蛋白表达与临床病理特征及预后的相关性分析
董金菊,周庆红,李菲
0
(湖北医药学院附属襄阳市第一人民医院妇科)
摘要:
【摘要】 目的 探讨宫颈癌组织中Bcl2相互作用的细胞死亡调解因子(BIM)与BH3only蛋白家族中p53上调凋亡调控因子(PUMA)的表达情况,并分析BIM与PUMA在宫颈癌组织中的临床病理特征及预后相关性。方法 选取本院2013年4月~2015年4月收治的124例宫颈癌患者,行回顾性分析,将124例宫颈癌患者癌组织标本124份设为研究组,选取124份其他良性宫颈疾病的正常组织标本为对照组,所有组织标本均行BIM与PUMA检测,分析宫颈癌组织中BIM与PUMA的表达与患者临床病理特征和预后的关系。结果 研究组中BIM、PUMA表达水平低于对照组(P<0.05);两组BIM、PUMA的表达与宫颈癌患者年龄、肿瘤大小、病理类型及肌层浸润深度情况均无明显关系(P>0.05);BIM的表达与宫颈癌国际妇产科联盟(FIGO)分期、淋巴结转移及分化程度的表达有关(P<0.05);FIGOⅡ期、有淋巴结转移、低分化及BIM、PUMA蛋白阴性患者其生存时间均显著缩短(P<0.05);经多因素Cox 比例风险回归模型分析得出FIGOⅡ期、有淋巴结转移、低分化及BIM、PUMA蛋白阴性均为影响宫颈癌患者预后的独立危险因素(P<0.05)。结论 BIM、PUMA蛋白在宫颈癌癌变组织中低水平表达,随着患者FIGO分期越高、有淋巴结转移、低分化时其低表达率均上升,且FIGOⅡ期、有淋巴结转移及低分化均为影响宫颈癌患者预后的独立危险因素。
关键词:  宫颈癌  凋亡诱导因子  免疫组织化  病理特征
DOI:
基金项目:湖北省科技厅自然科学基金面上项目
Correlation analysis of BIM and PUMA protein expression with clinical pathological features and prognosis in cervical cancer
DONG Jinju,ZHOU Qinghong,LI Fei
(Department of Gynaecology, Xiangyang No.1 People’s Hospital, Hubei University of Medicine;Department of Gynaecology, Xiangyang No.2 People’s Hospital, Hubei University of Medicine;Department of Gynaecology, Xiangyang No.3 People’s Hospital, Hubei University of Medicine)
Abstract:
【Abstract】 Objective To investigate expression of bcl2 interacting mediator of cell death (BIM) and p53 upregulated modulator of apoptosis (PUMA), so as to explore the correlation between BIM and PUMA in clinicopathological features and prognosis of cervical cancer. Methods The clinical data of 124 patients with cervical cancer admitted in our hospital from April 2013 to April 2015 were retrospectively analyzed. 124 cases of cervical cancer tissues (study group) and normal tissues specimens of other benign cervix diseases (control group) were collected. The BIM and PUMA of all the tissues were examined, and their correlation with the clinicopathological features and prognosis were analyzed. Results The expression of BIM and PUMA in cervical cancer tissues of cervical cancer patients was lower than that in adjacent normal tissues specimens of other benign cervix diseases(P<0.05). The expressions of BIM and PUMA were not significantly related to the age, tumor size, pathological type and myometrial invasion depth (P>0.05). The expression of BIM was related to FIGO stage, lymph node metastasis, and differentiation (P<005). The survival time of patients with FIGO stage II, lymph node metastasis, poorly differentiated, BIM, and negative PUMA protein was significantly shortened (P<0.05). The multivariate Cox proportional hazards regression analysis showed that FIGO stage II, lymph node metastasis, poorly differentiated and BIM, and negative PUMA protein were independent risk factors affecting the prognosis of cervical cancer patients (P<0.05). Conclusion The low expression of BIM and PUMA protein in cervical cancer tissues of cervical cancer patients is positively correlated with the FIGO stage II, lymph node metastasis, poorly differentiated, and those factors are the independent risk factors affecting the prognosis of cervical cancer patients.
Key words:  Apoptosis inducing factor  Cervical cancer  Immunohistochemistry  Pathological features

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