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维生素D及其受体与胃癌的相关性研究
韩川,时永全
0
(空军军医大学西京医院消化病医院肿瘤生物学国家重点实验室,火箭军峨眉疗养院)
摘要:
胃癌是中国第二大常见恶性肿瘤,也是癌症相关死亡的第三大主要原因。维生素D主要通过激活维生素D受体(VDR),抑制增殖,刺激凋亡和自噬、促进新生血管生成和转移潜能、调控免疫系统等,从而在其抗肿瘤机制中发挥重要作用。虽然流行病学结果不一致,但是从基础和临床试验中积累的证据表明,维生素D缺乏症可能会增加胃癌的风险和死亡率。因此,补充维生素D可能是一种安全、经济的预防或治疗胃癌的方法。本文就维生素D及其受体与胃癌的相关性研究进行了综述,并着重解析了流行病学结果不一致的可能原因。
关键词:  维生素D  维生素D受体  胃肿瘤  相关性
DOI:
基金项目:国家自然科学基金(81470805)
Association of serum vitamin D level and its receptor with gastric cancer
HAN Chuan,SHI Yongquan
(State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University,Rocket Army Emei Sanatorium)
Abstract:
Gastric cancer is the second most common malignancy and the second leading cause of cancerrelated deaths in China. Vitamin D plays an important role in its antitumor mechanism mainly by activating VDR, inhibiting proliferation, stimulating apoptosis and autophagy, promoting angiogenesis and metastatic potential, regulating immune system and so on. Although the epidemiological findings are not consistent, evidence from both basic and clinical trials suggests that vitamin D deficiency may increase the risk and mortality of gastric cancer, so vitamin D supplementation may be a safe and economical strategy for the prevention or treatment of gastric cancer. Here, we review the study of the association between gastric cancer and the level of Vitamin D, also with its receptor. More importantly, we highlight the possible causes of inconsistent epidemiological findings.
Key words:  Vitamin D  Vitamin D receptor  Gastric cancer  Association

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