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低频超声刺激对无机空心纳米微球药物释放影响的体外研究
李艳,朱冬梅,罗栩伟,刘学彬,杨姣,袁莉,张慧,刘刚
0
(南充市中心医院·川北医学院第二临床医学院)
摘要:
目的 研究低频超声对无机空心纳米微球携载药物释放的影响,并探讨无机空心纳米载体用作超声靶向药物治疗载体的可行性。方法 以植酸为调控剂,钙盐和亚硒酸盐为反应物,在水热条件下制备无机空心纳米微球。然后以牛血清白蛋白(BSA)为模型药物,载入无机空心纳米微球中,并给予低频超声刺激,测定BSA的释放量。结果 水热条件下成功制备了分散性良好的无机空心纳米微球,低频超声刺激下有利于加速纳米空心微球中BSA的释放,且BSA的释放率随低频超声功率的增加而加快。结论 本方法制备无机纳米空心微球简单、快速,且制备的微球分散良好。低频超声刺激有利于加速无机空心纳米微球中的药物释放速率。该微球有望用作低频超声靶向药物治疗载体。
关键词:  无机空心纳米微球  低频超声  植酸  超声靶向药物治疗截体
DOI:
基金项目:四川省卫生和计划生育委员会科研课题(18PJ149,16PJ201),四川省教育厅科研计划项目(17ZB0176),南充市应用技术研究与开发项目(16YFZJ0024),川北医学院科研发展计划项目(CBY17-A-YB19,CBY16-A-YB37)
Low frequency ultrasound stimulating drug release from inorganic hollow nanospheres in vitro
LI Yan,ZHU Dongmei,LUO Xuwei,LIU Xuebin,YANG Jiao,YUAN Li,ZHANG Hui,LIU Gang
(Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College)
Abstract:
Objective To study the effects of low frequency ultrasound on the drug release from inorganic hollow nanospheres and investigate the possibility of inorganic hollow nanospheres as the carrier of ultrasound targeted drug delivery system. Methods Using phytic acid as the modifier and calcium salt and selenite as reagent, inorganic hollow nanospheres were synthesized under hydrothermal condition. Then, bovine serum albumin as the model drug were loaded into the nanospheres and stimulated by low frequency ultrasound. The BSA release amount was measured under the low frequency ultrasound stimulus. Results Inorganic hollow nanospheres with good dispensability were successfully synthesized under hydrothermal condition. BSA release was facilated under ultrasound stimulus and BSA release rate increased with the ultrasound power. Conclusion This method is simple and effective to synthesize inorganic hollow nanospheres with good dispensability. Moreover, low frequency ultrasound stimulus is benefit to facilate drug release from inorganic hollow nanospheres. The inorganic hollow nanospheres could be a potent carrier of low frequency ultrasound targeted drug delivery system.
Key words:  Inorganic hollow nanospheres  Low frequency ultrasound  Phytic acid  Ultrasound targeted drug delivery system

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