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Lgr5调控Wnt/β Catenin信号通路与心血管疾病研究进展
黄磊,王秋林
0
(成都医学院第一附属医院心内科)
摘要:
【摘要】 心血管疾病的发病率和死亡率逐年上升,已成为威胁人类健康的重大疾病之一。过去Lgr5Wnt/βCatenin信号通路为肿瘤学研究热点。最新研究表明Wnt信号通路与心血管疾病存在密切联系,Lgr5作为Wnt/βCatenin信号通路受体蛋白亦被认为是心血管疾病潜在分子标记物。本文就Lgr5Wnt/βCatenin信号通路与心血管疾病的研究进展作一综述。
关键词:  心血管疾病  富含亮氨酸G蛋白偶联受体5  Wnt基因  β 连接蛋白  信号通路
DOI:
基金项目:四川省科技厅科技支撑计划项目(2016SZ0052)
Lgr5 regulation of Wnt/ beta Catenin signaling pathway in cardiovascular disease
HUANG Lei,WANG Qiulin
(Department of Cardiology, The First Affiliated Hospital of Chengdu Medical College)
Abstract:
【Abstract】 The morbidity and mortality of cardiovascular diseases increase year by year, and it has become one of the most important diseases threatening human health. Lgr5Wnt/βCatenin signaling pathway has been a hot topic in oncology. The latest research displays that the Wnt signaling pathway is closely related to cardiovascular diseases,as the receptor protein and targetgene of Wnt/βCatenin singeal,Lgr5 is also considered as the potential molecular marker of cardiovascular diseases.we introduced the Lgr5Wnt/βCatenin and overciewed the research progress the relationship between Lgr5Wnt/βCatenin and cardiovasular diseases in recent years.
Key words:  Cardiovascular disease  Leucine rich G protein coupled receptor 5  Wntgene  β catenin  Signaling pathway

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