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丙酸氟替卡松气雾剂联合西替利嗪治疗小儿季节性过敏性鼻炎的临床效果
邹杨,余海波,唐成忠
0
(乐山市人民医院耳鼻咽喉头颈外科;绵阳四零四医院急诊科)
摘要:
【摘要】 目的 探讨丙酸氟替卡松气雾剂联合西替利嗪治疗小儿季节性过敏性鼻炎的临床效果。 方法 选取2013年12月~2014年12月两院收治的100例小儿季节性过敏性鼻炎患儿作为研究对象,按照随机数字表法分为观察组和对照组,每组50例。观察组使用丙酸氟替卡松气雾剂联合西替利嗪治疗,对照组使用丙酸氟替卡松气雾剂治疗,12周为一个疗程。治疗结束后,记录两组临床治疗效果及治疗前后的体征等级;比较两组在停止治疗后1年内的复发次数及复发率;比较两组血液中嗜酸性粒细胞的比例;记录治疗期间两组不良反应发生的情况。结果 观察组总有效率优于对照组(P<005);治疗后,两组流涕、鼻塞、喷嚏、鼻甲肿大和体征分级评分均有下降(P<005),嗜酸性粒细胞百分比下降(P<005);与对照组相比,观察组体征分级评分及嗜酸性粒细胞百分比下降(P<005);观察组在结束治疗1年内过敏性鼻炎复发3次以下的概率、复发3~5次的概率、复发5次以上的概率、总复发率优于对照组(P<005);两组患儿在治疗期间均未发生不良反应。结论 丙酸氟替卡松气雾剂联合西替利嗪治疗小儿季节性过敏性鼻炎疗效良好,可在临床推广。
关键词:  西替利嗪  丙酸氟替卡松气雾剂  小儿季节性过敏性鼻炎  嗜酸性粒细胞
DOI:
基金项目:四川省卫生厅科研课题(13PJ188)
Clinical observation of cetirizine for seasonal allergic rhinitis in children
ZOU Yang,YU Haibo,TANG Chengzhong
(Department of Head, Neck and ENT Surgery, Leshan People's Hospital;Department of Emergency, Mianyang 404 Hospital)
Abstract:
【Abstract】 Objective To investigate the clinical observation of fluticasone propionate aerosol combined with cetirizine in children with seasonal allergic rhinitis. Methods 100 children with seasonal allergic rhinitis admitted to two hospitals from December 2013 to December 2014 were selected as study subjects and divided into observation group and control group, according to random number table method. The observation group was treated with fluticasone propionate aerosol combined with cetirizine. The control group fluticasone propionate aerosol treatment, 12 weeks for a course of treatment. The clinical curative effect, adverse reactions, the grade of the symptoms and the proportion of eosinophils of the two groups before and after treatment were observed. Results The total effective rate and markedly effective rate of the observation group were 9400% and 6200%, respectively, and the total effective rate was significantly better than that of the control group (8000%) (P<005). After treatment, the scores of nasal mucosa, nasal obstruction, sneeze, turbinate and signs grading were significantly decreased (P<005) and the percentage of eosinophils decreased significantly (P<005). In the observation group, the probability of allergic rhinitis recurrence less than 3 times within one year after treatment was 638%. The recurrence rate was 313%. The probability of recurrence more than 5 times was 0. The total recurrence rate was 851%. Those of observation group were better than that of the control group (P<005).Conclusion Fluticasone propionate aerosol combined with cetirizine treatment of children with seasonal allergic rhinitis has good effect.
Key words:  Cetirizine  Fluticasone propionate aerosol  Seasonal allergic rhinitis in children  Eosinophils

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