引用本文:[点击复制]
[点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 71次   下载 19 本文二维码信息
码上扫一扫!
右美托咪定靶控输注在冠状动脉搭桥术中的作用
刘德军,杨国庆,张顺,田永仓,解洪涛,柏本健
0
(陕西中医药大学第二附属医院1.麻醉科;心胸外科)
摘要:
【摘要】 目的 研究右美托咪定靶控输注在冠状动脉搭桥术 (CABG) 中的作用。方法 纳入2015年1 月~2017年10月于我院行CABG治疗的94例冠心病患者,数字法随机分为观察组与对照组,每组各47例。两组均采用常规气管插管全麻,观察组在此基础上进行右美托咪定靶控输注,对照组输注等量生理盐水。将麻醉诱导前、麻醉后、插管前、插管后及插管后5min设为T0、T1、T2、T3、T4,比较各时间点两组动脉舒张压(DBP)、收缩压(SBP)、平均动脉压(MAP)、心率(HR)、HR与SBP乘积(RPP)以及手术时间、拔管时间、苏醒时间。结果 两组T0、T1、T2 HR、RPP比较差异均无统计学意义(P>005),T3、T4观察组HR低于对照组,差异具有统计学意义(P<005); 两组T0、T1、T2DBP、SBP、MAP比较差异均无统计学意义(P>005),T3、T4观察组DBP、SBP、MAP均低于对照组,差异具有统计学意义(P<005);两组手术时间比较差异无统计学意义(P>005);观察组苏醒时间、拔管时间低于对照组,差异具有统计学意义(P<005)。结论 冠心病冠状动脉搭桥术治疗运用右美托咪定靶控输注能够降低插管后血压与心率,即减轻气管插管时心血管反应及心肌耗氧。
关键词:  右美托咪定  冠状动脉搭桥术  冠心病  靶控输注
DOI:
基金项目:陕西省社会发展攻关项目(2014K17 01)
Effects of target controlled infusion of dexmedetomidine on coronary artery bypass grafting
LIU Dejun,YANG Guoqing,ZHANG Shun,TIAN Yongcang,XIE Hongtao,BO Benjian
(Department of Anesthesiology, The Second Affiliated Hospital of Shanxi University of Traditional Chinese Medicine;Department of Surgery, The Second Affiliated Hospital of Shanxi University of Traditional Chinese Medicine)
Abstract:
【Abstract】 Objective To investigate the effects of targetcontrolled infusion of dexmedetomidine on coronary artery bypass grafting. Methods In this study, 94 patients with coronary heart disease undergoing CABG in our hospital from January 2015 to October 2017 were selected and randomly divided into observation group and control group, each group 47 cases. All patients received conventional tracheal intubation general anesthesia. Based on this, the observation cases received the targetcontrolled infusion of dexmedetomidine. The control group cases were infused with the same amount of saline. The levels of diastolic blood pressure (DBP), systolic blood pressure (SBP), MAP, HR and RPP were recorded before induction (T0), after drug injection (T1), before intubation (T2) and 5min after intubation (T3), then the operation time, extubation time and awakening time were also recorded. Results The HR and RPP of the two groups at the T0, T1,T2 had no significant difference (P>005). The HR at the T3 and T4 in the observation group were significantly lower than those in the control group (P<005). The DBP, SBP and MAP of the two groups at the T0, T1,T2 had no significant difference (P>005). The DBP, SBP and MAP at the T3 and T4 in the observation group were significantly lower than those in the control group (P<005). The operation time of the two groups had no significant difference (P>005). The extubation time and awakening time of the observation group were significantly shorter than those in the control group (P<005). Conclusion The application of targetcontrolled infusion of dexmedetomidine on coronary artery bypass grafting in coronary heart disease can reduce the blood pressure and heart rate after intubation, which means that cardiovascular response and myocardial oxygen consumption will be reduced during the intubation.
Key words:  Dexmedetomidine  CABG  Coronary heart disease  Target controlled infusion

用微信扫一扫

用微信扫一扫