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鼻渊通窍颗粒联合匹多莫德治疗儿童过敏性鼻炎的临床研究
喻望博,李蕊,李婉,程文丽,潘庆春
0
(川北医学院附属医院 1.耳鼻咽喉头颈外科;妇产科;四川省南充卫生学校附属医院)
摘要:
【摘要】 目的 研究全反式维甲酸(ATRA)联合亚砷酸(ATO)对NPM1阳性老年非早幼粒细胞急性髓细胞白血病( nonAPL AML)患者的疗效。方法 选取2012年2月~2017年2月我院收治的NPM1老年非早幼粒细胞AML患者76例为研究对象。将其按照随机数字表法均分成观察组和对照组,每组各38例。对照组予以小剂量阿糖胞苷(LDAC)化疗,观察组则在LDAC基础上联合ATO及ATRA化疗。分别比较两组早期死亡率、完全缓解率、复发率情况,不良反应发生情况以及1年生存率情况。结果 观察组完全缓解率高于对照组,而复发率低于对照组,差异有统计学意义(均P<005)。两组肝功能损害、胃肠道反应以及头痛发生率比较差异无统计学意义(均P>005)。观察组1年生存率高于对照组,差异有统计学意义(P<005)。结论 应用ATRA联合ATO及LDAC使老年NPM1阳性 nonAPL AML患者完全缓解率,降低复发率,延长1年生存率,具有较高的安全性,值得临床进一步研究。
关键词:  儿童过敏性鼻炎  鼻渊通窍颗粒  匹多莫德
DOI:
基金项目:四川省卫计委科研课题(17PJ537)
Clinical study on treatment of children 's allergic rhinitis with Biyuan Tongqiao Granule and Pidotimod
YU Wangbo,LI Rui,LI wan,CHENG Wenli,PAN Qingchun
(Department of ENT, The Affiliated Hospital of North Sichuan Medical College;Department of Gynaecology and Obstetrics, The Affiliated Hospital of North Sichuan Medical College;Nanchong Health School Affiliated Hospital)
Abstract:
【Abstract】 Objective To observe the clinical efficacy of Biyuan Tongqiao granule combined with pidotimod in children with allergic rhinitis and provide clinical data for the treatment of allergic rhinitis. Methods 213 children with allergic rhinitis were randomly divided into group A, group B and group C. The group A, group B and group C were treated with nasolabria through Tongqiao granule, Pidotimod, and Xueyuan Tongqiao granule combined with Pidotimod, respectively. Clinical symptom scores before and after treatment, nasal secretion of inflammatory substances, clinical indicators and adverse reactions were observed.Results The clinical symptom scores, nasal secretions inflammatory substances content and clinical indicators of the three groups were significangly different(P<005). The clinical symptom scores, nasal secretions inflammatory substances content and clinical indicators of group C were lower than that of group A and group C. The nausea/vomiting, bosom frowsty, total number of adverse reactions of the three groups were siginificant different. The nausea/vomiting, bosom frowsty, total number of adverse reactions of group C were lower than that of group A and group C. Conclusion BHD can be clinically effective in treating childhood allergic rhinitis.
Key words:  Children with allergic rhinitis  Nasal Yuan Tongqiao particles  Pidotimod

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