引用本文:[点击复制]
[点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 27次   下载 9 本文二维码信息
码上扫一扫!
RECK、MMP 9在三阴性乳腺癌组织芯片中的表达及临床意义
张靖,徐卫云,张晓红,赵丽娟,张珍,唐卓葳,龙丽
0
(绵阳市中心医院乳腺外科)
摘要:
【摘要】 目的 探讨基质金属蛋白酶抑制剂(RECK)、基质金属蛋白酶9(MMP9)在三阴性乳腺癌(TNBC)组织、癌旁组织中的表达及与TNBC临床病理的关系。方法 选择绵阳市中心医院乳腺外科2011年5月~2013年7月经病理证实为TNBC的72例石蜡标本及同患者癌旁组织,利用免疫组化组织芯片技术检测其RECK、MMP9蛋白的表达。结果 RECK在TNBC组织及癌旁组织中阳性表达率分别为4306%、8056%(P=0000)。TNBC中RECK的表达与临床分期(P=0009)、组织学分级(P=0010)、腋窝淋巴结转移情况(P=0000)相关。MMP9在TNBC组织及癌旁组织中阳性表达率分别为625%、1528%(P=0000)。TNBC中MMP9的表达与肿瘤大小(P=0017)、临床分期(P=0001)、组织学分级(P=0001)、腋窝淋巴结转移状况(P=0001)、Ki67表达情况(P=0034)相关。TNBC中RECK与MMP9表达呈负相关(r=0195,P<005)。结论 RECK的表达缺失与MMP9过度表达与TNBC浸润、转移有关,有望成为TNBC的预后指标,并且有可能成为TNBC治疗的靶点。
关键词:  基质金属蛋白酶抑制剂  基质金属蛋白酶 9  免疫组化组织芯片  三阴性乳腺癌
DOI:
基金项目:四川省绵阳市卫生局科研计划项目(201218)
Expression of RECK and MMP 9 in tissue microarray of triple negative breast cancer and its clinical significance
ZHANG Jing,XU Weiyun,ZHANG Xiaohong,ZHAO Lijuan,ZHANG Zhen,TANG Zhuowei,LONG Li
(Department of Breast Surgery, Mianyang Central Hospital)
Abstract:
【Abstract】 Objective To investigate the expression of matrix metalloproteinase inhibitor (RECK), matrix metalloproteinase9 (MMP9) in triple negative breast cancer(TNBC) and adjacent tissues of TNBC and its relationship with the clinicopathology of TNBC.Methods Immunohistochemical tissue microarray technique was used to detect the expression of RECK and MMP9 in 72 cases of TNBC and 72 cases of adjacent tissues.Results The positive expression rates of RECK in TNBC and paracancerous tissues were 4306% and 8056% (P=0000). The expression of RECK in TNBC was correlated with clinical stage (P=0.009), histological grade (P=0. 010) and axillary lymph node metastasis(P=0. 000). The positive expression rates of MMP9 in TNBC and paracancerous tissues were 625% and 1528% (P=0000). The expression of MMP9 in TNBC was correlated with tumor size(P=0017), clinical stage (P=0001), histological grade (P=0001) and axillary lymph node metastasis (P=0034). Negative correlation between RECK and MMP-9 expression in TNBC(r=-0195,P<005).Conclusion The lack of expression of RECK and overexpression of MMP9 are important biological indicators in the invasion and metastasis of TNBC, which may be the target of TNBC treatment.
Key words:  RECK  MMP 9  Immunohistochemical tissue microarray  Triple negative breast cancer

用微信扫一扫

用微信扫一扫