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HIV/AIDS相关机会性感染研究进展
杜凌遥,唐红
0
(四川大学华西医院感染性疾疾病中心)
摘要:
【摘要】 机会性感染是人类免疫缺陷病毒(HIV)感染者进入艾滋病期的重要标准,也是HIV感染者主要的不良临床事件,严重影响患者预后。了解HIV/AIDS相关机会性感染的主要种类,识别机会性感染发生的危险因素,掌握机会性感染的诊疗原则,可以有效预防其发生,控制其进展;也是提高HIV患者生存质量,降低死亡率的关键。通过尽早启动抗逆转录病毒治疗(ART)来恢复细胞免疫功能是预防机会性感染的最佳手段;而根据患者CD4细胞计数,适时启动预防性抗菌药物治疗也有非常重要的作用。总之,在HIV感染者,尤其细胞免疫被严重抑制的患者中,应定期筛查机会性感染,做到早期诊断、早期治疗,才能改善预后。本文就HIV/AIDS相关机会性感染研究进展作一综述。
关键词:  人类免疫缺陷病毒  艾滋病  机会性感染  抗逆转录病毒治疗
DOI:
基金项目:国家科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”(2012ZX10004-901)
Advances in HIV/AIDS related Opportunistic Infections
DU Lingyao,TANG Hong
(Center of Infectious Diseases, West China Hospital of Sichuan University)
Abstract:
【Abstract】 Opportunistic infections (OIs) are critical criteria to distinguish patients with Acquired Immune Deficiency Syndrome (AIDS) from Human Immunodeficiency Virus (HIV) infected patients. And they are also dominant adverse events in HIV infected patients. To learn the types of HIV/AIDS related OIs, the risk factors and principles on diagnosis and treatment would effectively prevent the occurrence of OIs and retard the progress of diseases. Thus, these measures would help to improve patients’ life quality and decrease the mortality. Early initiation of antiretroviral therapy (ART) to restore cellular immunity is key method to prevent OIs and initiation of preventative antibiotics administration upon CD4 cell count also works. In conclusion, in severe immunosuppressive HIV infected patients, routine screening of OIs, early diagnosis and early intervention would improve the long term prognosis of patients.
Key words:  Human Immunodeficiency Virus  Acquired Immune Deficiency Syndrome  Opportunistic Infections  Antiretroviral Therapy

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