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NT-proBNP联合GDF 15检测对单纯主动脉瓣关闭不全心力衰竭患者的诊断价值*
艾山木,蒋东坡,王鸿
0
(解放军陆军军医大学第三附属医院(野战外科研究所)重症医学科;重庆市东南医院重症医学科)
摘要:
【摘要】 目的 探讨N末端B型利钠肽原(NTproBNP)联合血浆生长分化因子15(GDF15)检测对单纯主动脉瓣关闭不全(AR)心力衰竭患者的诊断价值。方法 选择2014年3月~2016年12月陆军军医大学第三附院医院收治的138例单纯AR心力衰竭患者和同期体检的32例正常健康者为研究对象,采用酶联免疫法和ELISA法对血浆NTproBNP和GDF15进行检测,评价其诊断价值。结果 与正常对照组相比,单纯AR心力衰竭组NTproBNP和GDF15水平均显著升高(P<005),心力衰竭Ⅰ级与Ⅱ级间差异无统计学意义(P>005);心力衰竭Ⅲ级与Ⅰ、Ⅱ级间差异有统计学意义(P<005),提示NTproBNP联合GDF15检测对单纯AR心力衰竭的诊断具有较高临床价值。结论 检测NTproBNP和GDF15水平,并结合心功能等资料有利于筛查AR严重心力衰竭患者,对临床诊断与治疗具有重要的指导意义。
关键词:  N末端B型利钠肽原  生长分化因子 15  单纯主动脉瓣关闭不全  心力衰竭
DOI:
基金项目:
Diagnostic value of N terminal B type natriuretic peptide combined with plasma growth factor 15 in patients with simple aortic regurgitation and heart failure
AI Shanmu,JIANG Dongpo,WANG Hong
(Intensive Medicine Department, The Third Affiliated Hospital of the Army Medical University of the People's Liberation Army;Intensive Medicine Department, Chongqing Dongnan Hospital)
Abstract:
【Abstract】 Objective To investigate the diagnostic value of NTproBNP and GDF15 in patients with simple aortic valve insufficiency. Methods 138 AR patients with heart failure and 32 normal controls from March 2014 to December 2016 in our hospital were enrolled in this study. The diagnostic value of GDF15 with Enzymelinked immunosorbent assay (ELISA) was evaluated. Results NTproBNP and GDF15 levels were significantly increased in ARtreated group (P<005) compared with those in normal control group. There was no significant difference between gradeⅠand Ⅱin heart failure (P>005). There was significant difference between grade Ⅲ andⅠ, Ⅱin heart failure (P<005). NTproBNP combined with GDF15 levels in the diagnosis of AR alone heart failure, the combination of the two had a high clinical value for the diagnosis of AR severe heart failure. Conclusion The detection of NTproBNP and GDF15 levels combined with cardiac function and other data is conducive to the screening of patients with severe failure, which has important guiding significance for clinical diagnosis and treatment.
Key words:  N terminal pro brain natriuretic peptide  Growth differentiation factor 15  Simple aortic valve insufficiency  Heart failure

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