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促甲状腺素受体在亚临床甲状腺功能减退小鼠心室肌的表达及意义
白丹,倪菁,雷飞,严喜章,马建梅
0
(西安医学院临床医学院)
摘要:
【摘要】 目的 探讨促甲状腺素受体(TSHR)在亚临床甲状腺功能减退(SCH)小鼠心室肌的表达及意义。方法 30只BALB/c小鼠随机分为对照组及实验组,每组15只。实验组小鼠构造亚临床甲状腺功能减退动物模型,对照组小鼠饮用正常水,腹腔注射等量生理盐水。比较两组小鼠超声心动图检测结果,血清TT3、TT4、TSH水平。免疫组织化学染色法检测各组小鼠心室肌组织中TSHR的表达情况。结果 两组超声心动图检测结果显示,实验组E/E’值高于对照组(P<001)。两组TT3水平比较差异无统计学意义(P>005);实验组血清TT4水平明显低于对照组,血清TSH水平明显高于对照组(P<001)。免疫组织化学染色结果显示,实验组心室肌组织中TSHR表达明显高于对照组。结论〓当发生亚临床甲状腺功能减退时,心室肌组织TSHR表达上调,与高浓度的TSH结合后可能通过某种机制影响心脏舒缩功能。
关键词:  亚临床甲状腺功能减退  心室肌  心功能  促甲状腺素
DOI:
基金项目:陕西省教育厅科技计划专项(17JK0667);西安医学院校级课题(2016QN 14)
Study on the expression and significance of TSHR in SCH mice ventricular muscle
BAI Dan,NI Jing,LEI Fei,YAN Xizhang,MA Jianmei
(School of Clinical Medicine, Xi’an Medical University)
Abstract:
【Abstract】 Objective To explore the expression and significance of TSHR in SCH mice ventricular muscle.Methods The 30 BALB/c mice were randomly divided into the control group and the experiment group (n=15). The model of hypothyroidism was produced in the experimental group. The echocardiography, TT3, TT4 and TSH levels were observed. The immunohistochemical staining method was used to detect the expression of TSHR in the ventricular muscle tissues of mice.Results The results of echocardiography showed that the E/E’ value of the experiment group was significantly higher than that of the control group, and the difference was statistically significant (P<001). The serum TSH levels in the experiment group were significantly lower than those in the control group, and the serum TSH level was significantly higher than that in the control group (P<001). The mouse model was successful in the experimental group. The results of immunohistochemical staining showed that TSHR expression in the experimental group was significantly higher than that in the control group.Conclusion When subclinical hypothyroidism occurs, the TSHR expression of the ventricular muscle tissue is increased, which may affect the function of cardiac function by some mechanism after binding with high concentration of TSH.
Key words:  Subclinical hypothyroidism  Ventricular muscle  Cardiac function  Thyroid stimulating hormone

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