引用本文:[点击复制]
[点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 85次   下载 21 本文二维码信息
码上扫一扫!
干细胞治疗狼疮肾炎及银屑病的现状和前景
刘毅,熊安吉
0
(四川大学华西医院风湿免疫科)
摘要:
干细胞是一类具有自我复制能力的多潜能分化细胞,在一定条件下可以分化成多种功能细胞,去替代机体那些死亡并且不能再生的细胞,以期达到治愈的效果。对于无法再生的细胞损伤,干细胞治疗显得不可替代。目前全球已经有多种干细胞产品用于治疗临床疾病,例如骨关节炎、心肌梗死和糖尿病等。自身免疫性疾病存在免疫的异常,而干细胞又具有良好的免疫调节作用。因此,干细胞对于自身免疫性疾病的治疗优势不仅在于干细胞可以分化再生为功能细胞,替代和修复死亡和受损伤的细胞,而且干细胞具有的免疫调节作用,还可以在自身免疫性疾病的发病机制环节进行干预和阻止,治疗效果和前景较其他疾病更具有优势。遗憾的是,截至目前国内外尚无干细胞产品上市用于治疗自身免疫性疾病。本文结合目前国内外关于干细胞治疗自身免疫性疾病的临床研究及个案报道,就干细胞产品用于治疗狼疮肾炎及银屑病的现状和前景做一述评。
关键词:  干细胞  狼疮肾炎  银屑病  应用
DOI:
基金项目:科技部国家重点研发计划项目(2016YFC0906201)
The current status and prospects of stem cells for application in lupus nephritis and psoriasis
LIU Yi,XIONG Anji
(Department of Rheumatology and Immunology, West China Hospital, Sichuan University)
Abstract:
Stem cells are a kind of multipotential differentiated cells with the ability of selfreplication. Under certain conditions, they can differentiate into multiple functional cells and replace the dead and nonregenerating cells to achieve the curative effects. Stem cell therapy is irreplaceable for nonregenerative cell injury. Currently, various stem cell products have been approved for the treatment of clinical diseases, such as osteoarthritis, myocardial infarction and diabetes. Autoimmune diseases have immune disorders, while stem cells can regulate immune. Advantages of stem cells for the treatment of autoimmune diseases, therefore, is not only that stem cells can differentiate regeneration for function cell, replace and repair the death and damaged cells, stem cells have the immune adjustment function, which can intervene and prevent the development of autoimmune diseases. The treatment effects and prospect of stem cells application in autoimmune diseases have more advantages than other diseases. Unfortunately, up to now, there are no stem cell products available worldwide for the treatment of autoimmune diseases. Based on the current available stem cell products and clinical studies on stem cells treatment in autoimmune diseases, We predict which stem cell products are most likely to be used for autoimmune diseases.
Key words:  Stem cells  Lupus nephritis  Psoriasis  Application

用微信扫一扫

用微信扫一扫