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免疫球蛋白与糖尿病肾病研究进展
李含雨,刘芳
0
(四川大学华西医院肾内科)
摘要:
【摘要】 糖尿病肾病是糖尿病最常见的并发症,也是目前导致终末期肾脏疾病的首要原因,糖尿病肾病的发病机制复杂,其中遗传、炎症、免疫应答、内分泌等多种机制参与其中,但具体机制尚不十分清楚。IgG、IgM等免疫球蛋白被发现存在于糖尿病肾病患者的肾脏、血液及尿液中,且与患者的疾病进展、预后密切相关,本文就糖尿病肾病和免疫球蛋白的研究进展作一综述.
关键词:  糖尿病肾病  免疫球蛋白  体液免疫
DOI:
基金项目:国家自然科学基金
Progress in the study of immunoglobulin and diabetic nephropathy
LI Hanyu,LIU Fang
(Division of Nephrology, West China Hospital, Sichuan University)
Abstract:
【Abstract】 As the most common complication of diabetes, diabetic nephropathy is also the leading cause of endstage renal disease nowadays. The pathogenesis of diabetic nephropathy is complicated, involving multiple mechanisms such as genes, inflammation, immune response and endocrine and so on. However, the specific mechanism has remained unclear yet. It is found that IgG and IgM immuneglobulin exist in the kidney, blood and urine of patients with diabetic nephropathy, which is closely related to the disease progression and prognosis of patients. The paper provides an overview on the research progress of diabetic nephropathy and immunoglobulin.
Key words:  Diabetic nephropathy  Immunoglobulin  Humoral immunity

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