引用本文:[点击复制]
[点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 38次   下载 19 本文二维码信息
码上扫一扫!
丹参多酚酸盐联合氯沙坦钾对老年糖尿病肾病相关因素的影响
陈军,周海舟,王育林,吴绮楠
0
(陆军军医大学第一附属医院内分泌代谢科;陆军军医大学第一附属医院门诊部)
摘要:
【摘要】 目的 探讨丹参多酚酸盐联合氯沙坦钾对老年糖尿病肾病(DN)患者肾功能、凝血功能及血管内皮功能的影响。方法 选取我院2016年10月~2017年10月期间收治的老年DN患者120例,随机分为对照组和观察组两组,每组各60例,对照组采用常规内科治疗,并给予氯沙坦钾片治疗;观察组在对照组基础上加用丹参多酚酸盐。比较两组患者临床疗效及治疗前后肾功能、凝血功能、血管内皮功能、血清炎性因子及血脂等相关指标变化情况。结果 治疗后,观察组总有效率明显高于对照组,差异有统计学意义(P=0001);治疗后,两组患者SCr、BUN、24小时 Upro、FIB、PT、ET1、vWF、hsCRP、TNFα、IL6、TG、TC、LDLC水平均降低(P<005),且观察组降低幅度明显大于对照组,差异有统计学意义(P<005);治疗后,两组患者APTT、NO、HDLC水平升高(P<005),且观察组变化明显大于对照组,差异有统计学意义(P<005)。结论 丹参多酚酸盐联合氯沙坦钾治疗老年DN患者,可明显改善肾功能、纤溶活性及内皮功能,有效降低炎性因子水平。
关键词:  丹参多酚酸盐  氯沙坦钾  糖尿病肾病  肾功能  凝血功能  血管内皮功能
DOI:
基金项目:重庆市自然科学基金
Effects of salvianolate and losartan on renal function, coagulation function and vascular endothelial function in elderly
CHEN Jun,ZHOU Haizhou,WANG Yulin,WU Qinan
(Department of Endocrine Metabolism, The First Affiliated Hospital of Army Medical University;Department of Outpatient, The First Affiliated Hospital of Army Medical University)
Abstract:
【Abstract】 Objective To investigate the effects of salvianolate and losartan on renal function, coagulation function and vascular endothelial function in elderly patients with diabetic nephropathy (DN). Methods 120 patients with senile DN admitted to our hospital from October 2016 to October 2017 were selected and divided into two groups, each with 60 cases. The control group received routine medical treatment and losartan tablets. Based on the treatment of control group, the observation group received the salvianolate. The clinical efficacy and renal function[serum creatinine (SCr), urea nitrogen (BUN), 24hour urinary protein (24h Upro)], coagulation function[activated partial thromboplastin time (APTT), plasma fibrinogen (FIB), Plasma Prothrombin Time (PT)], endothelial function[Nitric Oxide (NO), Endothelin1 (ET1), Vascular Hemophilia Factor (vWF)], serum inflammatory factors[Highsensitivity Creactive protein (hsCRP), tumor necrosis factorα (TNFα), interleukin6 (IL6)]and blood lipids[triglycerides (TG), total cholesterol (TC), Lowdensity lipoprotein cholesterol (LDLC), highdensity lipoprotein cholesterol (HDLC)], and other related indicators change before and after treatment were compared between the two groups. Results After treatment, the total effective rate in the observation group was significantly higher than that in the control group (8667% vs 6000%, 2=10909, P=0001). The levels of SCr, BUN, 24h Upro, FIB, PT, ET1, vWF, hsCRP, TNFα, IL6, TG, TC, and LDLC were decreased in both groups after treatment (P<005), and the decreasing level was more obvious in the observation group than in the control group (P<005). The APTT, NO, and HDLC levels were increased in both groups (P<005), and the increasing level was more obvious in the observation group than in the control group (P<005). Conclusion The salvianolate combined with losartan can significantly ameliorate the renal function, fibrinolytic activity and endothelial function, and effectively reduce the level of inflammatory factors for senile DN patients.
Key words:  Salvianolate  Losartan  DN  Renal function  Coagulation function  Vascular endothelial function

用微信扫一扫

用微信扫一扫