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银杏酮酯滴丸与苯磺酸左旋氨氯地平和厄贝沙坦用于治疗老年高血压的疗效和安全性
任黔玲,周溯,马良金,魏华莲,胡珀,赖小利
0
(四川石油管理局总医院药剂科)
摘要:
【摘要】 目的 观察银杏酮酯滴丸与苯磺酸左旋氨氯地平和厄贝沙坦联用治疗原发性老年高血压的临床疗效和安全性。方法 将90例原发性老年高血压患者随机分为实验组和对照组各45例。对照组给予苯磺酸左旋氨氯地平片5 mg,每日1 次早晨口服+厄贝沙坦分散片150 mg,每日1次早晨口服。治疗组在对照组治疗基础上加服银杏酮酯滴丸8丸,每日3次。两组均连续治疗6个月。比较两组患者24 h 动态血压监测和心率监测变化、实验室检查指标(血脂、血糖、肝肾功能、血尿常规、心电图及血流动力学等检测结果)和药物不良反应。结果 连续治疗6个月后,两组患者的血压均达到长期、持续、稳定下降,降血压作用显著,24小时动态血压、总体有效率、心率、血糖和肝功能指标比较,差异无统计学意义(P>005);但治疗组能够显著改善患者的尿微量白蛋白、GFR、胱抑素、血脂水平以及血流动力学指标,差异均有统计学意义(P<005);治疗组不良反应发生率为667%,低于对照组133%,差异有统计学意义(P<005)。结论 银杏酮酯滴丸联合苯磺酸左旋氨氯地平与厄贝沙坦治疗原发性老年高血压患者降压效果更加平稳、持久,安全性更好,可放心应用于临床。
关键词:  银杏酮酯滴丸  苯磺酸左旋氨氯地平  厄贝沙坦  疗效  安全性
DOI:
基金项目:四川省医学会科研课题(2016SHD013)
Clinical effects and safety of Yinxing Tongzhi Dripping Pills on elderly patients with primary hypertension
REN Qianling,ZHOU Su,MA Liangjin,WEI Hualian,HU Po,LAI Xiaoli
(Pharmacy Department, General Hospital of Sichuan Petroleum Administration)
Abstract:
【Objective】 To explore the effects and safety of the combination regime of Yinxing Tongzhi Dripping Pills, levamlodipine besylate and irbesartan. Methods 90 patients were randomly divided into the control group treated with levamlodipine besylate and irbesartan and treatment group treated with Yinxing Tongzhi Dripping Pills, levamlodipine besylate and irbesartan. The treatment duration lasted for 6 months. At the end of 6 months, comprehensive efficacies including pressure changes and adverse drug reactions were recorded. Results After 6 months’ treatment, obvious lowering effects of blood pressure in both groups were observed without statistical significance (P>005). Microalbuminuria levels, GFR, cystatin, serum lipid levels and hemodynamic index in the treatment group were significantly higher than that of the control group (P<005). Conclusion The combination regime of Yinxing Tongzhi Dripping Pills, levamlodipine besylate and irbesartan is stable, persistent and safe for elderly patients with primary hypertension.
Key words:  Yinxing Tongzhi Dripping Pills  Levamlodipine  Besylate  Irbesartan  Efficacy  Safety

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