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高龄COPD患者稳定期长期吸入激素对骨密度的影响
周雨田,李小惠,陈果,刘杨渝,郭姝瑾
0
(四川省医学科学院·四川省人民医院老年呼吸科)
摘要:
【摘要】 目的 探讨长期吸入激素后对于稳定期慢性阻塞性肺疾病(COPD)高龄患者(年龄>75岁)的骨密度的影响。方法 纳入年龄>75岁且符合COPD稳定期诊断标准患者60例,随机分为治疗组和对照组各30例。治疗组每日吸入信必可160ug/45ug12次/日,对照组不使用吸入或者静脉用激素。1年前后观察患者骨密度(BMD)及骨代谢指标变化[血清钙离子,骨钙素(BGP)、骨碱性磷酸酶(BAP)、β胶原特殊序列(βCrosslaps)]。结果 两组患者年龄、性别、体重等指标无统计学差异(P>005)。治疗前后,两组患者组内对比,骨密度及骨代谢指标差异无统计学意义(P>005)。治疗前后两组患者组间比较,骨密度及骨代谢指标差异无统计学意义(P>005)。结论 COPD稳定期患者使用吸入激素<1年的情况下未见骨密度降低。
关键词:  COPD  稳定期;吸入激素;骨密度
DOI:
基金项目:四川省卫生厅干部保健科研课题(30305030516)
The effects of long term inhaled corticosteroids on bone mineral density in stable elderly patients with COPD
ZHOU Yutian,LI Xiaohui,CHENG Guo,LIU Yangyu,GUO Shujin
(Department of Geriatric Respiratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital)
Abstract:
【Abstract】 Objective To investigate the effect of longterm inhaled corticosteroids on bone mineral density in elderly patients with stable COPD. Methods 60 COPD stable phase patients older than 75 years old were enrolled, and were randomly divided into treatment group and control group. The treatment group inhaled Symbicort (160ug/45ug) once or twice per day. The control group did not use any corticosteroids. Their bone mineral density and bone metabolic indexes (serum Calcium. Osteocalcin (BGP), Bone Alkaline Phosphatase (BAP)) were tested after 1 year. Results There was no significant difference in bone mineral density between the two groups and before and after treatment (P>005). The results of bone metabolic indexes were similar to those of bone mineral density. Conclusion There is no decreas of bone mineral density in the COPD stable phase patients who inhaled corticosteroids for long term.
Key words:  COPD  Stablestage  Inhaled corticosteroid  Bone mineral density

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