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宫颈癌患者手术前后血清及病变组织AGR2水平变化及其临床意义
王钧,李蔚范
0
(北京市丰台中西医结合医院妇产科;北京大学肿瘤医院妇科)
摘要:
【摘要】 目的 检测宫颈癌及宫颈上皮内瘤样病变(CIN)患者手术前后血清及病变组织前梯度蛋白2(AGR2)水平变化,并探讨其临床意义。方法 采用酶联免疫吸附法(ELISA)分别对30例宫颈癌患者(宫颈癌组)和20例CIN患者(CIN组)手术前后血清及病变组织,另选20例正常健康体检女性血清样本以及因子宫肌瘤行全子宫切除术患者的正常宫颈组织为对照组检测AGR2水平。结果 宫颈癌患者手术前血清及癌组织AGR2水平明显高于CIN和正常对照组(均P<001),宫颈癌及CIN患者术后血清AGR2水平较术前明显降低(均P<001);宫颈癌组织及血清AGR2水平与肿瘤大小、FIGO分期、淋巴结转移相关(P<001或005);Pearson宫颈癌及CIN患者术前血清AGR2与术后血清AGR2水平呈正相关(r=0747,P=0000),宫颈组织AGR2水平与手术前后血清AGR2水平均呈正相关(r=0789,P=0000;r=0700,P=0000)。结论 宫颈癌患者血清及病变组织AGR2增高,与肿瘤大小、FIGO分期、淋巴结转移相关,可为临床手术疗效和预后的判断提供一定的参考依据。
关键词:  宫颈癌  前梯度蛋白2  CIN
DOI:
基金项目:
Significance and changes of AGR2 level in tissue and serum of patients with cervical cancer before and after operation
WANG Jun,Li Weifan
(Department of Obstetrics and Gynecology, Fengtai Chinese Traditional and Western Medicine Hospital of Beijing;Department of Gynecology, Peking University Cancer Hospital)
Abstract:
【Abstract】 Objective To detect the changes of anterior gradient2 (AGR2) level before and after operation in tissue and serum of patients with cervical intraepithelial neoplasia (CIN) and cervical cancer, and to explore its clinical significance. Methods The serum and tissue of patients with cervical cancer (n=30) and patients with CIN (n=20) before and after operation were collected. Serum sample from 20 health women and cervix tissue samples of 20 patients undertaken total hysterectomy due to myoma were collected for the control group. AGR2 levels were detected by enzymelinked immunosorbent assay (ELISA). Results The levels of AGR2 in preoperative serum and tissues of cervical cancer were significantly higher than that of CIN and normal control group (all P<001). The levels of serum AGR2 after operation in the cervical cancer and CIN patients were significantly lower than that of preoperative (all P<001). The AGR2 levels of serum and tissue of cervical cancer patients were significantly different for the tumor size, FIGO stages and lymph node involvement (P<001 or 005). Pearson analysis showed that serum AGR2 levels before operation positively correlated to that after operation in the patients with CIN and cervical cancer (r=0747,P=0000). The levels of serum AGR2 before and after operation positively correlated to that in cervical tissue (r=0789,P=0000;r=0700,P=0000). Conclusion The levels of AGR2 in serum and tissue of cervical cancer increased obviously, which was closely related to tumor size, FIGO stages and lymph node involvement. It is valuable to dectect the level of AGR2 for judging the surgical curative effect of patients with cervical cancer.
Key words:  Cervical cancer  Anterior gradient2

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