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双环醇对抗神经病药所致肝损伤脂质过氧化的抑制作用
李斐,赵英歌,李德生,胡容
0
(解放军总医院药学部临床药学中心,北京 100853;解放军总医院 药品供应中心,北京 100853;解放军总医院 内科临床部神经内科,北京 100853)
摘要:
目的 探讨双环醇对抗神经病药所致肝损伤脂质过氧化的抑制作用。方法 选择2013年6月~2016年6月在我院就诊的抗神经病药所致肝损伤患者98例,采用随机数字表法将患者分为研究组和对照组各49例。对照组患者给予甘草酸二铵胶囊治疗,研究组患者给予双环醇片治疗,对患者的疗效进行判定,并检测患者的总胆红素、丙氨酸转氨酶、γ-谷氨酰转肽酶、天冬氨酸转氨酶和磷酸酶,观察两组患者血清丙二醛(MDA)、超氧化物岐化酶(SOD)水平,并记录两组患者不良反应。结果 治疗后,两组患者肝功能指标均有显著降低,且研究组改善效果较对照组显著,差异均有统计学意义(P<0.05);治疗后,两组患者SOD活性较治疗前提高,且研究组活性高于对照组;两组患者的MDA活性显著降低,且研究组显著低于对照组,差异均有统计学意义(P<0.05);研究组患者中24例显效,16例有效,总有效率为81.63%,显著高于对照组(P<0.05);两组患者治疗期间均未发生药物不良反应。结论 双环醇能显著改善抗神经病药所致肝损伤患者的肝功能,显著抑制机体脂质过氧化作用,且具有较好的安全性,可在临床推广使用。
关键词:  双环醇  肝损伤  脂质过氧化  抑制作用
DOI:
基金项目:解放军总医院科技创新苗圃基金项目(16KMM55)
Inhibition effect of bicyclol on lipid peroxidation in liver injury induced by neuropathic drugs
LI Fei,ZHAO Yingge,LI Desheng,HU Rong
(Pharmacy Department, Clinical Pharmacy Center, General Hospital of PLA, Beijing 100853, China;;Drug Supply Center, General Hospital of PLA, Beijing 100853, China;Neurology Department, Department of Intenal Medicine, General Hospital of PLA, Beijing 100853,China)
Abstract:
Objective To investigate the inhibitory effects of bicyclol on lipid peroxidation in liver injury induced by neuropathic drugs. Methods 98 patients with anti nerve druginduced liver injury were selected from June 2013 to June 2016 in our hospital. The patients were randomly divided into study group and control group. Two groups of patients were given general support. The control group was treated with Diammonium Glycyrrhizinate Capsules treatment. The study group was given the treatment criteria standard of Bicyclol Tablets. The efficacy, the total bilirubin, alanine aminotransferase, gamma glutamyl aminotransferase, aspartate aminotransferase and phosphatase were detected. The serum levels of malondialdehyde, superoxide dismutase level and the adverse reactions were observed. Results After treatment, the indexes of liver function of study group and control group were significantly reduced. The indexes of liver function of study group significantly improved compared with that of the control group (P<0.05). The activity of SOD of study group and control group improved after treatment. The activity of SOD of the study group was higher than that of control group. The MDA activity of study group was lower than that of control group (P<0.05). The patients in There were 24 cases and 16 cases cured in study group and control group. The total effective rate of study group (81.63%) was higher than that of control group (P<0.05). There was no drug adverse reaction of the two groups. Conclusion Bicyclol can improve the liver function of liver injury induced by neuropathic drugs and inhibit the lipid peroxidation.
Key words:  Bicyclol  Liver injury  Lipid peroxidation  Inhibition

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