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达克罗宁胶浆抑制高血压患者全麻气管拔管期间的心血管反应效果
李刚,喻红彪,曾锦明,冯周恒,张玉林
0
(川北医学院第二临床医学院·南充市中心医院麻醉科,四川 南充 637000)
摘要:
目的 观察达克罗宁胶浆抑制高血压患者气管拔管期间心血管反应的效果。方法 选择行气管插管全麻手术患者80例,随机分为两组,每组40例。两组在气管插管前1min均采用2%利多卡因溶液喷雾患者的咽喉部及声门。对照组在气管导管前端1/3处均匀涂抹2ml石蜡油;观察组用等量达克罗宁胶浆涂抹气管导管相同部位,两组其余处理方法相同。观察并记录两组患者麻醉前(T0)、插管前1min(T1)、插管时(T2)、插管后1min(T3)、插管后3min(T4)、拔管前1min(T5)、拔管时(T6)、拔管后1min(T7)、拔管后3min(T8)、拔管后5min(T9)各时点收缩压(SBP)、舒张压(DBP)、心率(HR)的变化,及拔管前后苏醒期躁动评分、导管耐受程度、术后24h内咽喉疼痛、声音嘶哑的发生情况。结果 在T0~T4时点两组SBP、DBP、HR差异无统计学意义(P>0.05),T5~T8时点观察组SBP、DBP、HR均低于对照组(P<0.05),观察组拔管前后苏醒期躁动评分低于对照组,导管耐受程度高于对照组(P<0.05);两组术后咽喉痛、声音嘶哑的发生率差异无统计学意义(P>0.05)。结论 达克罗宁胶浆能有效维持高血压患者气管拔管期间循环稳定,减少苏醒期躁动发生率,值得临床推广使用。
关键词:  达克罗宁  高血压  麻醉  拔管
DOI:
基金项目:国家自然科学基金(81171472);四川省教育厅重点项目(11ZA188)
The effects of dyclonine muciluge on stress reaction during extubation in patients with hypertension
LI Gang,YU Hongbiao,ZENG Jingmin,FENG Zhouheng,ZHANG Yulin
(Department of Anesthesia, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong 637000, Sichuan, China)
Abstract:
Objective To evaluate the effect of dyclonine mucilage on stress reaction during extubation in patients with hypertension.Methods 80 patients undergoing general anesthesia were randomly divided into two groups, with 40 cases in each group. 2% lidocaine were sprayed to the throat and glottis of the patients 1min before the intubation in two groups. The control group was smeared with 2mL paraffin oil on the distal third of tracheal tube before intubation. The observation group was treated with dyclonine in the same position. The other anesthesia measures were equal in two groups. The SBP, DBP, HR and agitation score and tolerance for tube, pharyngalgia and hoarseness in both groups were observed before anesthesia (T0),at 1min before intubation (T1), at intubation (T2), at 1 min, 3 min after intubation (T3, 4),at 1 min before extubation (T5), at extubation (T6),at1, 3, 5min after extubation (T7, 8, 9). Results There was no significant difference in SBP, DBP and HR between groups at T0-T4(P>0.05). The SBP, DBP and HR in observation group were lower than control group at T5-T8(P<0.05). The agitation score and tolerance for tube in observation group were lower than control group at T5-T8(P<0.05). There was no significant difference in pharyngalgia and hoarseness between the groups. Conclusion Dyclonine mucilage can effectively relieve the cardiovascular response during extubation and reduce the adverse reactions during recovery.
Key words:  Dyclonine  Hypertension  Anesthesia  Extubation

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