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MicroRNA21的生理作用及其在缺血性心脏病中的研究进展
刘杰,赵玲琼,胡厚祥
0
(川北医学院附属医院心血管内科;重庆医科大学附属第二医院肿瘤科)
摘要:
【摘要】〓MicroRNA(miRNA)是一类由22个左右核苷酸组成的高度保守的非编码小RNA分子,可通过抑制靶基因mRNA的翻译或通过促进mRNA降解对靶基因起到负性调控的作用。miRNA的生物功能复杂多样,与心脑血管疾病、肿瘤、血液系统疾病及肝脏疾病等也有密切关系。目前已发现数千种miRNA,miR21是miRNA家族中的一员,参与心血管系统的多种生理及病理过程,近年来发现在缺血性心脏病中具有重要作用。本文就miR21在缺血性心脏病的相关研究进展作一综述。
关键词:  MicroRNA  MicroRNA21  缺血  缺氧  心肌损伤  缺血性心脏病
DOI:
基金项目:国家自然科学基金青年科学基金资助项目(81600232)
Study of the physiological function of microRNA 21 and its application in ischemic heart disease
LIU Jie,ZHAO Lingqiong,HU Houxiang
(Department of Cardiology, The Affiliated Hospital of North Sichuan Medical College;Department of Oncology, The Second Affiliated Hospital of Chongqing Medical University)
Abstract:
【Abstract】〓Composed of about 22 nucleotides, microRNA are a class of small, strongly conserved throughout evolution noncoding RNA molecules. MicroRNAs regulate gene expressions by suppressing the translation of the messenger RNA of target genes or by promoting mRNA degradation. The biological function of microRNA is complex and diverse, and has a close relationship with cardiovascular disease, tumor, blood system diseases and liver diseases and so on. Thousands of microRNA to been found, and microRNA21 is a member of the microRNAs. MicroRNA21 is involved in many physiological and pathological processes of cardiovascular system. In recent years, it has been found to play an important role in ischemic heart disease. This review article summarizes the research progress regarding the microRNA21 and its relationship with myocardial ischemic heart disease.
Key words:  microRNA  microRNA 21  Ischemia  hypoxia  Myocardial injury  Ischemic heart disease

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