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氟西汀对抑郁症患者血清CD3 CD4和CD8细胞水平及糖脂代谢的影响
卜琴芳,陈方斌,张李婉,强亮
0
(常州102医院精神科)
摘要:
【摘要】〓目的〓探讨氟西汀对抑郁症患者血清CD3、CD4和CD8细胞水平及糖脂代谢的影响。方法〓回顾性分析我院采用氟西汀治疗的86例抑郁症患者临床资料,并设为试验组;将同期我院米氮平治疗的82例抑郁症患者作为对照组,比较两组患者治疗前后汉密尔顿抑郁量表(HAMD)评分、CD3、CD4和CD8细胞水平及糖脂代谢的变化。结果〓治疗前两组患者HAMD 评分差异无统计学意义(P>005);治疗后4、8周试验组HAMD 评分下降,且低于同期对照组,差异有统计学意义(P<005)。治疗前两组患者CD3、CD4和CD8细胞水平差异无统计学意义(P>005);治疗后4、8周试验组CD3、CD4和CD8细胞水平升高,并呈逐渐升高的趋势,同时也高于同期对照组,差异均有统计学意义(P<005)。治疗前两组患者2hPG、FPG、HbAlc、TC、TG、LDL、HDL水平差异无统计学意义(P>005);治疗后4、8周试验组2hFG、FPG、HbAlc水平下降,并呈逐渐下降的趋势,同时也低于同期对照组,差异均有统计学意义(P<005);治疗后4、8周试验组TC、TG、LDL水平无明显变化(P>005),但低于同期对照组(P<005);而治疗后4、8周试验组HDL无明显变化(P>005),但高于同期对照组,差异有统计学意义(P<005)。结论〓氟西汀可有效改善抑郁症患者临床症状,增强机体免疫力,不同程度地改善糖代谢紊乱,对血脂影响则较小,可在临床选择应用。
关键词:  氟西汀  抑郁症  CD3、CD4和CD8细胞  糖脂代谢
DOI:
基金项目:江苏省自然科学基金资助项目(BJK2011374)
Effects of fluoxetine on serum CD3, CD4 and CD8 levels and glucose and lipid metabolism in patients with depression
BO Qinfang,CHEN Fangbin,ZHANG Liwan,QIANG Liang
(Department of Psychiatry, 102 Hospital of Changzhou)
Abstract:
【Abstract】〓Objective〓To investigate the effect of fluoxetine on CD3, CD4 and CD8 cell levels and glucose and lipid metabolism in patients with depression. Methods〓A retrospective analysis of 86 patients of depression treated with fluoxetine in clinical data of the patients were set as the experimental group, and 82 patients with depression treated with mirtazapine in the same period were taken as the control group. HAMD score, CD3, CD4 and CD8 cell levels and glucose and lipid metabolism were measured before and after treatment. Results〓There was no significant difference in HAMD score between the two groups before treatment (P> 005), 4 weeks after treatment and 8 weeks after treatment (P <005). The levels of CD3, CD4 and CD8 were not significantly different between the two groups before treatment (P> 005). The levels of CD3, CD4 and CD8 increased at 4 weeks and 8 weeks after treatment, and increased gradually (P> 005). There was no significant difference in 2hPG,FPG,HbAlc,TC,TG,LDLand HDL levels between the two groups before treatment (P> 005). The levels of FG, FPG and HbAlc decreased at 4 weeks and 8 weeks after treatment, and decreased gradually and lower than that of the control group (P <005). The levels of TC, TG and LDL in the experimental group at 4 weeks and 8 weeks after treatment were not significantly different (P> 005), which was significantly lower than that of the control group (P <005). There was no significant difference in HDL between the four weeks and the 8 weeks after treatment(P>005), which was significantly higher than that of the control group (P <005). Conclusion〓Fluoxetine can effectively improve the clinical symptoms of patients with depression, enhance immunity, different degrees of improvement of glucose metabolism disorders, the impact of lipid is small, worthy of clinical choice.
Key words:  Fluoxetine  Depression  CD3  CD4  CD8  Glycolipid metabolism  

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