引用本文:[点击复制]
[点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 565次   下载 147 本文二维码信息
码上扫一扫!
尖吻蝮蛇血凝酶在成人腺样体肥大手术中的止血效果和安全性研究
夏炎,魏宏权,杜莉,田慧,李雅莉
0
(中国医科大学附属第四医院耳鼻咽喉科)
摘要:
【摘要】〓目的〓评价尖吻蝮蛇血凝酶(Haemoczxoagulase Agkistrodon,HCA, 商品名:苏灵)在成人腺样体肥大手术中的止血效果和安全性。 方法〓采取双盲和随机对照的方法,将手术患者50例随机分为实验组(A组)25例,术前半小时静注尖吻蝮蛇血凝酶2U;对照组(B组)25例,术前半小时静注生理盐水作为安慰剂模拟尖吻蝮蛇血凝酶。记录术中出血量、手术时间和血压波动范围等,并于术后第1d查凝血功能、血常规和肝功能等安全性指标进行观察。结果〓实验组止血有效率为76%,对照组止血有效率为21%,组间术中出血量的控制差异有统计学意义(P<005);两组术前与术后血常规各指标变化比较差异均有统计学意义(P<005);两组术前与术后的ALT、TBIL、Bun、Cr及PT、TT、APTT、FIB的变化比较差异均无统计学意义(P>005)。结论〓尖吻蝮蛇血凝酶对成人腺样体肥大手术切口有较好的止血效果和安全性。
关键词:  尖吻蝮蛇血凝酶  腺样体肥大  止血效果  安全性
DOI:
基金项目:辽宁省科学技术计划项目(2011205027)
he research of hemostatic efficacy and safety of hemocoagulase agkistrodon in adults adenoid hypertrophy in surgery
XIA Yan,WEI Hongquan,DU Li,TIAN Hui,LI Yali
(Department of Otolaryngology, The Fourth Affiliated Hospital of China Medical University)
Abstract:
【Abstract】〓Objective〓To evaluate the hemostatic efficacy and safety of hemocoagulase agkistrodon in adenoid hypertrophy surgery.Methods〓50 operated patients were randomly divided into experimental group (25 cases) treated with hemocoagulase agkistrodon 2 u half an hour before operation, control group (25 cases) treated with physiological saline half an hour before operation. The intraoperative blood loss, operating time and blood pressure range, blood coagulation functions such as safety, routine blood and liver function index were observed.Results〓The hemostatic effective rate of experimental group and control group were 76% and 21%. The blood coagulation function and the function of liver and kidney of experimental group and control group were had no statistical significance (P > 005). The difference of interoperative blood loss of experimental group and control group was statistically significant(P<005). The various indicators in routine blood of the experimental group before and after operation were statistical significant (P<005). The operation index of control group before and after operation was statistically significant(P<005). The changes of ALT, TBIL, Bun and Cr of experimental group and control group before and after operation had no statistically significant difference (P>005). The changes of PT, TT, APTT and FIB of experimental group and control group before and after operation had no statistical significant difference (P>005). Conclusion〓The hemocoagulase agkistrodon has hemostatic funtion in sadenoidectomy hypertrophy in adults surgery.
Key words:  Hemocoagulase agkistrodon  Adenoid hypertrophy  Hemorrhagic  Safety

用微信扫一扫

用微信扫一扫