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六合丹对家兔皮肤感染创面愈合过程中SPMMP1及bFGF表达的影响
吕长遥,伍静,龚翰林
0
(四川大学华西医院中西医结合科)
摘要:
【摘要】〓目的〓探讨六合丹对家兔创伤感染创面愈合过程中P物质(SP)、金属基质蛋白酶1(MMP1)及碱性成纤维细胞生长因子(bFGF)表达的影响,揭示六合丹促进伤口愈合的机制。方法〓麻醉满意后对40只兔子造模,每只兔子背部做5个直径2cm的圆形感染性创面,分为空白组、模型组、治疗组(六合丹)、西药组(藻酸钙敷料)、中药组(紫草油),术后第1d起开始每天换药。结果〓换药后第7、14和21d治疗组、西药组和空白组创面愈合率明显优于模型组和中药组(均P<005)。治疗组的愈合时间优于模型组、中药组(均P<005);治疗组的P物质(SP)在换药后3、7、14和21d有较强的表达,与模型组和中药组比较,差异均有显著性(P<005)。治疗组和西药组的MMP1在换药后7、14和21d均有较强的表达,与模型组和中药组比较,差异均有显著性(P<005)。治疗组的bFGF在换药后3、7和14d表达均强于中药组和模型组(P<005)。结论〓六合丹能显著促进家兔感染性创面中SP、MMP1、bFGF的分泌,刺激和诱导家兔感染性创面更快修复。
关键词:  六合丹  创面愈合  P物质  金属基质蛋白酶1  碱性成纤维细胞生长因子
DOI:
基金项目:四川省科技厅科研项目(2015SZ0134)
The impact of Liuhedan to SP, MMP1 and bFGF in infective wound healing of rabbits
LV Changyao,WU Jing,GONG Hanlin
(Department of Integrated Chinese and Western Medicine, West China Hospital)
Abstract:
【Abstract】〓Objective〓Liuhedan is produced by West China Hospital of Sichuan University, it is widely used in the treatment of acute inflammation,but less used in chronic inflammation and wound after surgery. This study applied Liuhedan to the infective wound of rabbits,in order to reveal the mechanism of promotion to wound healing. Methods〓 40 rabbits were modeled after anesthesia. 5 circular wounds were made on the back of each rabbit. Each wound was 2cm deep. Five wound divided into 5 groups including control group, model group, treatment group (Liuhedan), Western medicine group (Calcium Alginat) and Chinese medicine group (Lithospermum oil). Dressing changes were performed every day after surgery. Results〓At 3 days,7 days and 14 days after surgery,the wound healing rate of treatment group, Western medicine group and control group had statistically difference compared with model group and Chinese medicine group (P<005). The time of wound healing of treatment group had statistically difference compared with model group and Chinese medicine group (P<005). The expression of SP of treatment group was strong at 3 days, 7 days, 14 days and 21 days after surgery. There were statistically significant difference compared with model group and Chinese medicine group (P<005). The expression of MMP1 of treatment group and Western medicine group were strong at 7 days,14 days and 21 days after surgery. There were statistically significant difference compared with model group and Chinese medicine group (P<005). The expression of bFGF of treatment group was strong at 3 days, 7 days and 14 days after surgery. There were statistically significant difference compared with model group and Chinese medicine group (P<005).Conclusion〓Liuhedan could promote the secretion of SP, MMP1 and bFGF in infective wound of rabbits significantly, stimulate and induce infective wound to be repaired faster.
Key words:  Liuhedan  wound healing  SP  MMP1  bFGF

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