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肠道菌群失调与类风湿关节炎发病及疾病进展的相关性
方勇飞,刘晓飞
0
(第三军医大学第一附属医院中西医结合科·风湿免疫中心)
摘要:
【摘要】 类风湿关节炎(rheumatoid arthritis,RA)是一种常见的系统性自身免疫病,其发病原因仍不十分清楚;遗传和环境因素在其发病中起重要作用。近年来,越来越多的证据表明,肠道菌群失调影响RA的发病及疾病进展。本文就肠道菌群在类风湿关节炎发病中的研究进展做一述评。
关键词:  类风湿关节炎  肠道菌群  T细胞
DOI:
基金项目:国家自然科学基金资助项目(81072921)
Progress of intestinal flora in the pathogenesis of rheumatoid arthritis
FANG Yongfei,LIU Xiaofei
(Department of Integrated Medicine and Rheumatology, Southwest Hospital of The Third Military Medical University)
Abstract:
【Abstract】 Rheumatoid arthritis (RA) is a common systemic autoimmune disease, but its etiology and pathogenesis are still not very clear. Environmental and genetic factors are involved in the pathogenesis of rheumatoid arthritis. In recent years, more and more evidences have confirmed that the dysbiosis of intestinal flora have been associated with rheumatoid arthritis. In this review, we will focus on the association between intestinal microflora and the pathogenesis of RA.
Key words:  Rheumatoid arthritis  Intestinal flora  T cell

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