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AMI患者行PCI手术前后血BNP、NT-proBNP的变化及意义
金春,宋颖,祖武,吴曼
0
(阜新矿业(集团)有限责任公司总医院心血管科;唐山市人民医院心内科)
摘要:
【摘要】目的 探讨急性心肌梗死(AMI)患者行经皮冠状动脉介入治疗术(PCI)手术前后血BNP、NTproBNP的变化及意义。方法 选取阜新矿业(集团)有限责任公司总医院在2012年10月~2016年10月收治的734例AMI患者(killip分级ⅠⅢ级)作为对象,其中对照组242名,行静脉溶栓治疗,观察组492名,行PCI治疗。分别观察两组患者血BNP、NT-proBNP含量与心功能的关系、治疗前后血BNP、NT-proBNP含量及治疗后随访12个月两组患者心血管事件的发生率。结果 血浆中BNP、NT-proBNP含量在不同心功能级别中比较差异有统计学意义(P<0.05),且随着心功能不全程度的加重,BNP、NTproBNP含量也随之增加,各级别之间差异具有统计学意义(P<0.05);两组患者在治疗后,血BNP、NTproBNP含量均有显著下降(P<0.05),而观察组患者血BNP、NT-proBNP含量下降较溶栓性治疗组更显著(P<0.05);对两组患者随访12个月,对照组共发生159例心血管事件,占65.70%,观察组发生228例心血管事件,占46.34%,观察组的心血管事件发生率明显低于对照组(P<0.05)。结论 AMI患者血BNP、NT-proBNP含量显著升高,且血BNP、NTproBNP含量高的患者在治疗后出现心血管事件的风险也增加。
关键词:  急性心肌梗死  BNP  NT-proBNP
DOI:
基金项目:2016年度中国煤炭工业协会科学技术研究指导性计划项目(MTKJ 2016 348)
The changes and significance of BNP and NT-proBNP in blood before and after PCI in patients with AMI
JIN Chun,SONG Ying,ZU Wu,WU Man
(Department of Cardiology, General Hospital of Fuxin mining (Group) Co., Ltd.;Department of Cardiology, Tangshan People's Hospital)
Abstract:
【Abstract】Objective To explore the changes and significance of BNP and NTproBNP in blood before and after PCI in patients with AMI. Methods From October 2012 to October 2016, 734 acute myocardial infarction patients was studied in General Hospital of Fuxin mining (Group) Co., Ltd.. 242 patients were treated with thrombolytic therapy (control group). 492 patients were treated with PCI surgery (observation group). The relationship between the content of BNP, NT-proBNP and cardiac function were observed. The content of BNP, NT-proBNP and the incidence of cardiovascular events in the patients were observed before and after treatment for up to 12 months. Results The content of BNP and NT-proBNP in plasma in concentric function group had significant difference, and with the severity of cardiac insufficiency, BNP and NT-proBNP content also increased (P<0.05). The serum BNP, NT-proBNP after treatment significantly decreased (P<0.05). The blood BNP and NTproBNP of PCI treatment significantly decreased compared with thrombolytic therapy (P<0.05). There were 159 cases (65.70%) and 228 cases (46-34%) with cardiovascular events in control group and observation group, the observation group accounted for 4634%. The incidence of cardiovascular events of observation group was significantly lower than that of control group(P<0.05). Conclusion The levels of blood BNP and NT-proBNP in patients with myocardial infarction are significantly high, and the risk of cardiovascular events increased after treatment of patients with high blood BNP and NT-proBNP levels.
Key words:  Acute myocardial infarction  BNP  NT-proBNP

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