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胱抑素C与PLT计数在肝硬化中的临床应用分析
王军荐,胡宏章
0
(四川大学华西医院实验医学科)
摘要:
【摘要】目的 探讨血清胱抑素C(CysC)和PLT计数在肝硬化患者中的临床意义和应用价值。方法 分析116例肝硬化患者CysC水平与PLT计数的相关性,采用 Child-Pugh分级评价肝硬化患者肝功能,对于两者在肝硬化中的临床价值,应用受试者工作特性曲线(ROC)进行评价。结果〓CysC水平与PLT计数呈负相关(r=-0.89,P<0.01),CysC水平随着Child-Pugh分值和分级不断递增,各级间比较差异有统计学意义(P<0.01);CysC水平与ChildPugh分值呈正相关(r=0.821,P<0.01);1/PLT与CysC的ROC曲线下面积分别为0.83、0.85,两者ROC曲线下面积比较差异无统计学意义(Z=5.32, P=0.51)。结论〓CysC与PLT计数能较灵敏地反映肝脏功能的变化,联合检测可以准确预测肝功能损伤程度和病情轻重,在指导临床诊断及治疗肝硬化方面有重要参考价值,适宜在临床上推广应用。
关键词:  PLT计数  胱抑素C  ROC曲线  Child Pugh分级
DOI:
基金项目:国家自然科学基金项目(81401729)
Clinical application analysis of Cystatin and PLT counting in hepatic cirrhosis
WANG Junjian,HU Hongzhang
(Department of Laboratory Medicine, West China Hospital, Sichuan University)
Abstract:
【Abstract】Objective To investigate clinical application values and meaning of cystatin C and PLT counting in hepatic cirrhosis.Methods Relationship between PLT counting and cystatin C of 116 patients with hepatic cirrhosis was analyzed. ChildPugh grading was used to evaluate the liver functions of patients with hepatic cirhosis with receiver operating characteristic curve (ROC) and the value of them in patients with hepatic cirhosis.Results Significant inverse correlation were found between PLT counting and cystatin C (r=﹣0.89,P<0.01). Cystatin C increased with ChildPugh classification escalating (P<0.01). Cystatin C offered positive correlation with the childPugh integral (r=0.821,P<0.01). The areas of 1/PLT and cystatin C under ROC curve were 083 and 085. There were statistically significant differences in terms of the areas under ROC curve (Z=5.32,P=0.51). Conclusion Cystatin C and PLT counting can sensitively reflect of the changes of liver function, and are closely related. The combination application of cystatin C and PLT counting can accurately predict the degree of liver damage and the severity of the disease and have important reference value in guiding clinical diagnosis and treatment of hepatic cirrhosis.
Key words:  PLT counting  Cystatin C  ROC curve  Child-Pugh classification

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