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微生态制剂联合低聚果糖治疗对抗生素诱发腹泻患儿肠道菌群的影响
杨大亮,罗丹,王蓉
0
(深圳市宝安区松岗人民医院药剂科)
摘要:
【摘要】目的 探讨口服二甲双胍控糖效果不佳糖尿病患者起始胰岛素治疗方案的选择及安全性。方法 选取口服二甲双胍控糖效果不佳的2型糖尿病患者126例随机分为3组,在二甲双胍治疗基础上,分别联用西格列汀、起始剂量10 U/d胰岛素、起始剂量15 U/d胰岛素分别作为A组、B组、C组,治疗期间均根据血糖控制情况调整用药剂量,达到并维持空腹血糖≤56 mmol/L。记录3组血糖达标率、达标时间、低血糖反应;计算治疗前后体重指数(BMI)、体重差值,统计三组治疗前后空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋(HbA1c)、胰岛素抵抗指数(HOMAIR)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)。结果〓本研究中A组5例脱落,B组7例脱落,C组8例脱落。3组患者血糖达标率、低血糖反应发生率比较差异无统计学意义(P>005);C组血糖达标时间短于A组、B组(P<005),但A组、B组比较差异无统计学意义(P>005)。3组治疗后FPG、2hPG、HbA1c、HOMAIR均下降,FINS上升,同组治疗前后差异有统计学意义(P<005),但3组组间比较差异无统计学意义(P>005)。A组治疗前后BMI、体重差值低于B组、C组,差异有统计学意义(P<005),但B组、C组比较差异无统计学意义(P>005)。结论〓口服二甲双胍控糖效果不佳2型糖尿病患者联合西格列汀、甘精胰岛素均可获得理想的降糖效果,且加大基础甘精胰岛素方案起始用药剂量可缩短血糖达标时间,但西格列汀在控制体重上更具优势。
关键词:  微生态制剂  低聚果糖  抗生素诱发腹泻
DOI:
基金项目:
Effect of probiotic combined fructo oligosaccharid treatment on microflora of children infected with antibiotic associated diarrhea
YANG Daliang,LUO Dan,WANG Rong
(Department of Pharmacy, Songgang People’s Hospital)
Abstract:
【Abstract】Objective To investigate the effect of probiotic combined fructooligosaccharid treatment on microflora of neonatal children infected with antibiotic associated diarrhea. Methods 45 children with antibiotic associated diarrhea were divided into microecologic cure group, microecologic+fructooligosaccharid cure group and conventional cure group, 15 children in each group. Bifidtriple viable capsule were given to microecologic cure group compared with conventional cure group. Fructooligosaccharid were eaten in microecologic+fructooligosaccharid cure group compared with microecologic cure group. The time of recovery and population of major bacteria were compared. Results The time of recovery in conventional cure group were significantly higher than that in microecologic cure group and microecologic+fructooligosaccharid cure group (P<0.05). The population of bifidobacterium and lactobacillus in microecologic cure group and microecologic+fructooligosaccharid cure group were significantly higher than those in conventional cure group (P<0.05). The population of bifidobacterium in microecologic cure group and were significantly lower than that in microecologic+fructooligosaccharid cure group (P<0.05). The population of E.Coli in convention cure group were significantly higher than that in microecologic+fructooligosaccharid cure group (P<0.05). Conclusion Probiotic preparation combined microecologic+fructooligosaccharid treatment can improve population of bifidobacterium and lactobacillus and reduce antibiotic associated diarrhea of children. The effect of microecologic can be enhanced by fructooligosaccharid.
Key words:  Fructo-oligosaccharide  Probiotics  Antibiotic associated diarrhea

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