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神经元特异性烯醇化酶和25羟维生素D在ALL患儿血清的水平及临床意义
刘一岚,苏毅,易海,刘芳,邓锐,张姗
0
(成都军区总医院血液内科)
摘要:
【摘要】目的 观察神经元特异性烯醇化酶(NSE)和25-羟维生素D[25-(OH)D]在急性淋巴细胞白血病(ALL)患儿血清中的表达水平及其临床意义。方法 采取ELISA法检测65例ALL患儿(初诊37例,完全缓解17例,难治复发11例)和35例健康儿童血清中NSE和25(OH)D表达水平。分析ALL初诊患儿血清中NSE和25(OH)D水平与其临床病理特征间的相关性。动态观察37例初诊ALL患儿血清中NSE和25(OH)D水平。结果 与对照组和完全缓解组相比,ALL初诊组和复发难治组患儿血清中NSE水平显著升高,25(OH)D显著降低(P<0.01)。ALL初诊患儿血清中NSE和25-(OH)D的表达水平与其年龄、性别、FAB分型、肝肿大及淋巴结肿大无相关性(P>0.05),在外周血WBC和危险度分型方面差异有统计学意义(P<0.01)。动态观察37例ALL患儿发现完全缓解后其血清中NSE水平显著下降,25-(OH)D水平明显升高(P<0.01)。结论 ALL患儿血清中NSE和25(OH)D水平测定对ALL的发生、发展及预后评估具有一定的临床价值,值得进一步探讨。
关键词:  急性淋巴细胞白血病  儿童  神经元特异性烯醇化酶  25-羟维生素D
DOI:
基金项目:国家自然科学基金(81500132)
Serum levels and significance of NSE and 25-(OH)D in childhood acute lymphoblastic leukemia
LIU Yilan,SU Yi,YI Hai,LIU Fang,DENG Rui,ZHANG Shan
(Department of Hematology, Chengdu Military General Hospital of PLA)
Abstract:
【Abstract】Objective To observe serum levels of neuronspecific enolase (NSE) and 25 hydroxy vitamin D(25(OH)D) and explore its clinical significance. Methods Serum levels of NSE and 25(OH)D in 65 cases childhood ALL (including 37 newly diagnosed cases,17 complete remission cases, and 11 relapsed cases) and 35 health children were measured by enzyme linked immunosorbent assay (ELISA). Correlation between serum levels of NSE and 25(OH)D in newly diagnosed cases and its pathological characteristics was analyzed. Serum levels of NSE and 25(OH)D in newly diagnosed cases was analyzed by sequential observation. Results Compared to control group and complete remission group, serum level of NSE was obviously high, while 25(OH)D was remarkably lower, in newly diagnosed cases and relapsed cases (P<0.01). Serum levels of NSE and 25(OH)D of newly diagnosed cases were irrelevant to age, gender, FAB classification, hepatomegaly, and lymphadenectasis (P>0.05), and were closely relevant to white blood cell(WBC) of peripheral blood and risk classification (P<0.01). After complete remission, serum level of NSE was evidently decreased, while 25(OH)D was increased, by sequential observation(P<0.01). Conclusion Serum levels of NSE and 25-(OH)D has a certain clinical value for occurrence, development, and prognosis evaluation of childhood ALL.
Key words:  Acute lymphoblastic leukemia  Child  Neuron specific enolase  25 hydroxy vitamin D

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