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西格列汀联合阿卡波糖治疗Ⅱ型糖尿病对脂代谢紊乱与胰岛素抵抗的影响
庞静,李霞,徐杰,白小岗,马越
0
(延安大学附属医院内分泌科)
摘要:
【摘要】目的 探讨西格列汀联合阿卡波糖治疗Ⅱ型糖尿病及对脂代谢紊乱与胰岛素抵抗的影响。方法 118例Ⅱ型糖尿病患者依据抽签法分为对照组与实验组,各59例。对照组采用西格列汀治疗,实验组采用西格列汀联合阿卡波糖治疗。比较两组治疗3个月后疗效,并检测三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C),胰岛素抵抗指数(HOMAIR),血糖,胃肠激素,炎症因子的改变及不良反应情况。结果〓实验组总有效率高于对照组,差异有统计学意义(P<0.05)。实验组TG、TC、LDL-C均低于对照组,实验组HDL-C高于对照组(P<0.05)。实验组HOMAIR低于对照组(P<0.05)。实验组血糖、胃肠激素、炎症因子优于对照组(P<0.05)。两组不良反应比较差异无统计学意义(P>0.05)。结论〓西格列汀联合阿卡波糖用于Ⅱ型糖尿病的疗效肯定,可改善脂代谢紊乱及胰岛素抵抗,并可利于胃肠道激素及炎性因子的调节,可在临床上推广应用。
关键词:  Ⅱ型糖尿病  西格列汀  阿卡波糖  疗效  脂代谢紊乱  胰岛素抵抗
DOI:
基金项目:陕西省自然科学基金资助项目(2010K16-04)
Design and thermal characteristics analysis of power flexible LED packaging
PANG Jing,LI Xia,XU Jie,BAI Xiaogang,MA Yue
(Department of Endocrinology,Yan’an University Hospital)
Abstract:
【Abstract】Objective To research the sitagliptin jiont acarbose in treatment of type 2 diabetes and the effects on lipid metabolism disorder and insulin resistance. Methods 118 type 2 diabetes, according to the lottery method, were divided into control group and experimental group. The control group was treated with sitagliptin, and the experimental group was treated with sitagliptin jiont acarbose. The curative effect was compared between the two groups. Triacylglycerol (TG), total cholesterol (TC), highdensity lipoprotein (HDL-C), low density lipoprotein (LDL-C), insulin resistance index (HOMA IR), blood sugar, gastrointestinal hormone, inflammation factors changed, and adverse reactions were compared between the two groups. Results The total effective rate of experimental group (9661%) was higher than that of the control group (8644%) (P<0.05). The TG, TC, LDLC of experimental group was lower than that of the control group. The HDL-C of experimental group was higher than that of control group (P<0.05). HOMAIR of experimental group was lower than that of control group. Glucose, gastrointestinal hormones and inflammation factor of experimental group was better than that of control group (P<0.05). The adverse reactions was no differences between the two groups (P>0.05). Conclusion The curative effect of sitagliptin joint acarbose in treatment of type 2 diabetes can improve lipid metabolism disorder and insulin resistance, and conducive to the regulation of gastrointestinal hormones and inflammatory factors.
Key words:  Type 2 diabetes  Sitagliptin  Acarbose  Curative effect  Lipid metabolism disorder  Insulin resistance

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