引用本文:[点击复制]
[点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 35次   下载 6 本文二维码信息
码上扫一扫!
盲肠结扎穿孔脓毒症大鼠心肌损伤的相关研究
郑晓丽,陈芳,张小乔,刘伯毅
0
(十堰市太和医院·湖北医药学院附属医院综合医疗科)
摘要:
【摘要】目的 通过盲肠结扎穿孔脓毒症大鼠心肌细胞凋亡率的变化,探讨心肌细胞凋亡与心肌损伤的关系。方法 将40只健康雄性Wistar大鼠随机分为假手术组(SH组,n=20)及脓毒症组(CLP组,n=20),采用盲肠结扎穿孔法(CLP)制备脓毒症动物模型,24小时后,检测各组的血清脑钠肽(BNP)、肌钙蛋白I(cTnI)水平。观察心肌组织病理变化、心肌组织TNF-α的表达水平及心肌细胞凋亡率。结果 CLP组出现明显的心肌损伤,CLP组血清BNP、cTnI高于SH组(P<0.01),心肌组织TNFα、心肌细胞凋亡率高于SH组(P<0.01)。结论 心肌细胞凋亡在脓毒症心肌损伤发病机制中可能起着重要的作用。
关键词:  脓毒症  心肌损伤  细胞凋亡
DOI:
基金项目:十堰市科技局指导项目(2014Y17)
Study on the correlation of myocardial injury in septic rats induced by cecal ligation and Puncture
ZHENG Xiaoli,CHEN Fang,ZHANG Xiaoqiao,LIU Boyi
(Department of Geriatric Medicine & General Medicine, Taihe Hospital, Hubei University of Medicine)
Abstract:
【Abstract】Objective To investigate the role of myocardial apoptosis in sepsisinduced myocardial injury. Methods 40 healthy male Wistar rats were randomly divided into sham group (SH group, n = 20) and sepsis group (CLP group, n = 20),The sepsis models were established by cecal ligation and puncture (CLP). The levels of serum brain natriuretic peptide (BNP) and cardiac troponin I (cTnI) were detected 24 hours after treatment. The myocardial tissue pathological changes and the expression levels of TNF-α, apoptosis in myocardial tissue were observed. Results In CLP group,myocardial tissue was seriously injured. The levels of serum BNP and cTnI of CLP group were high than that of SH group (P<0.01). The levels of myocardial TNFα and apoptosis of CLP group were higher than that of SH group (P<0.01). Conclusion Myocardial apoptosis may play an important role in the pathogenesis of sepsisinduced myocardial injury.
Key words:  Sepsis  Myocardial injury  Apoptosis

用微信扫一扫

用微信扫一扫