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甲状腺功能亢进与心房颤动相关性的研究进展
黎国兴,李骊华
0
(重庆医科大学附属第一医院心内科)
摘要:
【摘要】 心脏是甲状腺激素重要的靶器官之一。甲状腺激素通过多种方式对心血管动力起调节作用,影响机体血流动力学,调节心脏功能。心房颤动(Artial fibrillation,AF)简称房颤,是临床上最常见的心律失常之一。甲状腺功能亢进症(hyperthyroidism)是由于甲状腺合成释放过多的甲状腺激素,造成机体代谢亢进和交感神经兴奋,引起心悸、出汗、进食和便次增多、体重减少的病症。大型临床试验研究显示,甲状腺功能亢进患者容易发生房颤,甲亢动物模型的房颤可诱导性及持续性均明显增加,表明甲亢是房颤的高危因素。而房颤促进心脏病变,可导致心力衰竭及致残、致死性脑血管意外,增加医疗负担,因此,甲状腺功能亢进对房颤的影响逐渐得到国内外研究者的关注。本文就近年来甲状腺功能亢进与房颤发生的关系和机制研究进展进行综述,以期为相应疾病预防与治疗提供借鉴。
关键词:  【关键词】 甲状腺激素  甲状腺功能亢进  房颤  心脏重构
DOI:
基金项目:重庆市卫生计生委医学科研项目(2016MSXM009)
Advances in hyperthyroidism induced artial fibrillation
LI Guoxing,LI Lihua
(Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University)
Abstract:
【Abstract】 Atrial fibrillation (AF) is a multifaceted condition with several potential contributing factors.Thyroid hormone may exert both genomic and nongenomic roles in the cardiovascular homeostasis.AF occurs in up to 15% of patients with hyperthyroidism,and is more common in men than in women.Experimental and clinical investigations showed that overt and subclinical hyperthyroidism are risk factors associated with the development of AF.As the most common cardiac complication of hyperthyroidism,AF is a complex disease with several possible mechanisms.The main goal of this review is to discuss the clinical and pathophysiological links between hyperthyroidism and AF,and its underlying molecular mechanisms.
Key words:  【Key words】 Thyroid hormones  Hyperthyroidism  Artial fibrillation  Atrial remodeling

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